调查慢性阻塞性肺疾病住院患者的活动情况：一项试点研究。
Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: a pilot study.
机构信息
Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
Heart Lung. 2010 Jul-Aug;39(4):319-30. doi: 10.1016/j.hrtlng.2009.09.004. Epub 2010 Apr 8.
OBJECTIVE
This study examined therapeutic mobility activity, and investigated whether serum levels of inflammatory biomarkers interleukin (IL)-6 and IL-10 varied between periods of rest and activity.
METHODS
This observational, exploratory study took place in a medical intensive care unit and in stepdown units at an urban, academic medical center managed by intensivists. Our sample included 17 adults with exacerbations of chronic obstructive pulmonary disease (COPD).
RESULTS
Our results indicate that activity can occur for about 20 minutes, early during a hospitalization, among critically ill adults with COPD exacerbations, and activity can progress safely over 2 days in an intensive-care or stepdown setting. Physical activity was low in intensity, as measured by actigraphy.
CONCLUSION
Although no significant differences were evident between serum inflammatory biomarkers at rest vs after activity in this small sample, trend-related data indicate that low-intensity activity has the potential to alter the inflammatory profile of hospitalized COPD adults.
目的
本研究考察了治疗性活动，并调查了炎症生物标志物白细胞介素 (IL)-6 和 IL-10 的血清水平在休息和活动期间是否存在差异。
方法
本观察性、探索性研究在一家城市学术医疗中心的重症监护病房和降阶梯病房进行，由重症监护医生管理。我们的样本包括 17 名患有慢性阻塞性肺疾病（COPD）加重的成年人。
结果
我们的结果表明，在患有 COPD 加重的危重病成年人住院早期，大约可以进行 20 分钟的活动，并且在重症监护或降阶梯环境中可以安全地进行 2 天的活动。活动强度低，通过活动记录仪测量。
结论
尽管在这个小样本中，休息和活动后血清炎症生物标志物之间没有明显差异，但趋势相关数据表明，低强度活动有可能改变住院 COPD 成年人的炎症特征。
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