Department of Surgery, Cooper University Hospital, Robert Wood Johnson Medical School, Camden, New Jersey.
Semin Plast Surg. 2009 May;23(2):148-54. doi: 10.1055/s-0029-1214167.
Osteomyelitis is an acute or chronic inflammatory process of the bone and its related structures secondary to an infection with pyogenic organisms. Because of the variety in disease presentations and pathophysiology of osteomyelitis, it is very difficult to evaluate in clinical studies. Therefore, animal models have been created for in vivo experimentation. A PubMed and OVID search was performed on March 31, 2008, using keywords osteomyelitis, animal model (rabbit, rat, mouse, avian, dog, sheep, and goat), and experimental osteomyelitis. The objective of this review was to provide a literature review of the animal models created to study osteomyelitis. The models were chosen based on historical relevance and clinical applicability. Numerous animal models exist to study both acute and chronic osteomyelitis. Many models have been created that allow investigators to study various aspects in the treatment and diagnosis of osteomyelitis. Based on the needs of investigators, an animal model must be carefully selected for ideal research, as no single model encompasses all aspects of osteomyelitis.
骨髓炎是一种由化脓性生物体感染引起的骨骼及其相关结构的急性或慢性炎症过程。由于骨髓炎的临床表现和病理生理学的多样性，在临床研究中很难进行评估。因此，已经创建了动物模型进行体内实验。2008 年 3 月 31 日，通过使用关键词骨髓炎、动物模型（兔、鼠、鼠、禽、犬、羊、山羊）和实验性骨髓炎，在 PubMed 和 OVID 上进行了搜索。本综述的目的是提供对用于研究骨髓炎的动物模型的文献综述。根据历史相关性和临床适用性选择了这些模型。存在许多动物模型来研究急性和慢性骨髓炎。已经创建了许多模型，允许研究人员研究骨髓炎治疗和诊断的各个方面。根据研究人员的需求，必须仔细选择动物模型以进行理想的研究，因为没有单一的模型可以涵盖骨髓炎的所有方面。
