饮食限制增强生殖干细胞的维持。
Dietary restriction enhances germline stem cell maintenance.
机构信息
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
出版信息
Aging Cell. 2010 Oct;9(5):916-8. doi: 10.1111/j.1474-9726.2010.00602.x.
Abstract
Dietary restriction (DR) increases lifespan in species ranging from yeast to primates, maintaining tissues in a youthful state and delaying reproductive senescence. However, little is known about the mechanisms by which this occurs. Here we demonstrate that, concurrent with extending lifespan, DR attenuates the age-related decline in male germline stem cell (GSC) number in Drosophila. These data support a model whereby DR enhances maintenance of GSCs to extend the reproductive period of animals subjected to adverse nutritional conditions. This represents the first example of DR maintaining an adult stem cell pool and suggests a potential mechanism by which DR might delay aging in the tissues of higher organisms.
摘要
饮食限制（DR）可延长从酵母到灵长类等各种物种的寿命，使组织保持年轻状态，并延缓生殖衰老。然而，对于这种现象发生的机制知之甚少。在这里，我们证明了，与延长寿命同时发生的是，DR 减弱了果蝇雄性生殖干细胞（GSC）数量随年龄的下降。这些数据支持了这样一种模型，即 DR 通过增强 GSC 的维持来延长处于不利营养条件下的动物的生殖期。这是 DR 维持成体干细胞池的第一个例子，并为 DR 可能延缓高等生物组织衰老的潜在机制提供了线索。
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本文引用的文献
1
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Science. 2009 Nov 13;326(5955):954-8. doi: 10.1126/science.1178343.
2
Insulin levels control female germline stem cell maintenance via the niche in Drosophila.胰岛素水平通过果蝇中的微环境控制雌性生殖系干细胞的维持。
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1117-21. doi: 10.1073/pnas.0809144106. Epub 2009 Jan 9.
3
Adult male nutrition and reproductive success in Drosophila melanogaster.黑腹果蝇成年雄性的营养与繁殖成功率
Evolution. 2008 Dec;62(12):3170-7. doi: 10.1111/j.1558-5646.2008.00515.x. Epub 2008 Sep 11.
4
Aging and survival: the genetics of life span extension by dietary restriction.衰老与生存：饮食限制延长寿命的遗传学
Annu Rev Biochem. 2008;77:727-54. doi: 10.1146/annurev.biochem.77.061206.171059.
5
Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis.自我更新因子的减少导致果蝇睾丸中干细胞微环境的老化。
Cell Stem Cell. 2007 Oct 11;1(4):470-8. doi: 10.1016/j.stem.2007.08.002.
6
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7
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Mech Ageing Dev. 1985 Dec;33(1):19-28. doi: 10.1016/0047-6374(85)90106-x.
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