The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Aging Cell. 2010 Oct;9(5):916-8. doi: 10.1111/j.1474-9726.2010.00602.x.
Dietary restriction (DR) increases lifespan in species ranging from yeast to primates, maintaining tissues in a youthful state and delaying reproductive senescence. However, little is known about the mechanisms by which this occurs. Here we demonstrate that, concurrent with extending lifespan, DR attenuates the age-related decline in male germline stem cell (GSC) number in Drosophila. These data support a model whereby DR enhances maintenance of GSCs to extend the reproductive period of animals subjected to adverse nutritional conditions. This represents the first example of DR maintaining an adult stem cell pool and suggests a potential mechanism by which DR might delay aging in the tissues of higher organisms.
饮食限制（DR）可延长从酵母到灵长类等各种物种的寿命，使组织保持年轻状态，并延缓生殖衰老。然而，对于这种现象发生的机制知之甚少。在这里，我们证明了，与延长寿命同时发生的是，DR 减弱了果蝇雄性生殖干细胞（GSC）数量随年龄的下降。这些数据支持了这样一种模型，即 DR 通过增强 GSC 的维持来延长处于不利营养条件下的动物的生殖期。这是 DR 维持成体干细胞池的第一个例子，并为 DR 可能延缓高等生物组织衰老的潜在机制提供了线索。
