Represas Represas Cristina, Botana Rial Maribel, Leiro Fernández Virginia, González Silva Ana Isabel, del Campo Pérez Víctor, Fernández-Villar Alberto
Grupo de Investigación en Enfermedades Respiratorias e Infecciosas, Complejo Hospitalario Universitario de Vigo, Vigo, España.
Arch Bronconeumol. 2010 Aug;46(8):426-32. doi: 10.1016/j.arbres.2010.04.008. Epub 2010 Jun 8.
To evaluate the agreement and the association with FEV(1), FEV(6) and FEV(1)/FEV(6) measured with the Vitalograph-COPD-6 portable device and the FEV(1), FVC and FEV(1)/FVC by conventional spirometry, and to analyse the validity of this device to detect obstruction.
A cross-sectional, descriptive, prospective study, that included 180 subjects. A conventional spirometry and one with the Vitalograph-COPD-6 were sequentially performed on them. The agreement was analysed [kappa index and interclass correlation coefficient (ICC)], as well as the association [Pearson correlation coefficient (r)], area under the ROC curve (AUC) of the FEV(1)/FEV(6) in detecting obstruction, and the sensitivity, specificity, predictive values (PPV and NPV), and probability ratios (PR+ and PR-) of the different FEV(1)/FEV(6) cut-off points in the detection of obstruction.
The prevalence of obstruction was 47%. The kappa index was 0.59 when an FEV(1)/FEV(6) < cut-off point of <0.7 was used. The ICC and the r between the FEV(1) measured by the two instruments, FEV(6) and FEV(1)/FEV(6) measured by the Vitalograph-COPD-6 and the FVC and FEV(1)/FVC determined by the spirometer were all greater than 0.92. The ROC AUC was 0.97. To detect obstruction, if the cut-off point of FEV(1)/FEV(6) (for COPD-6) was <0.70, the sensitivity, specificity, PPV, NPV, CR+ and CR- were, 58%, 100%, 100%, 73%, infinity and 0.42, respectively. For a cut-off point of <0.8, they were 96%, 76%, 78%, 96%, 3.8 and 0.05, respectively.
The portable Vitalograph-COPD6 device is precise for the detection of airway obstruction. The best sensitivity/specificity of FEV(1)/FEV(6) was obtained with cut-off points greater than 0.7.
评估使用维托拉呼吸仪-慢性阻塞性肺疾病-6便携式设备测量的FEV(1)、FEV(6)和FEV(1)/FEV(6)与通过传统肺量计测量的FEV(1)、FVC和FEV(1)/FVC之间的一致性及相关性，并分析该设备检测气道阻塞的有效性。
一项横断面、描述性、前瞻性研究，纳入180名受试者。对他们依次进行传统肺量计检查和维托拉呼吸仪-慢性阻塞性肺疾病-6检查。分析一致性（kappa指数和组内相关系数[ICC]）以及相关性[Pearson相关系数(r)]、FEV(1)/FEV(6)检测气道阻塞的ROC曲线下面积(AUC)，以及不同FEV(1)/FEV(6)截断点在检测气道阻塞时的敏感性、特异性、预测值(PPV和NPV)和概率比(PR+和PR-)。
气道阻塞患病率为47%。当使用FEV(1)/FEV(6)<截断点<0.7时，kappa指数为0.59。维托拉呼吸仪-慢性阻塞性肺疾病-6测量的FEV(1)、FEV(6)和FEV(1)/FEV(6)与肺量计测定的FVC和FEV(1)/FVC之间的ICC和r均大于0.92。ROC AUC为0.97。为检测气道阻塞，若FEV(1)/FEV(6)（针对慢性阻塞性肺疾病-6）的截断点<0.70，则敏感性、特异性、PPV、NPV、CR+和CR-分别为58%、100%、100%、73%、无穷大及0.42。对于截断点<0.8，它们分别为96%、76%、78%、96%、3.8及0.05。
便携式维托拉呼吸仪-慢性阻塞性肺疾病6设备在检测气道阻塞方面较为精确。FEV(1)/FEV(6)在截断点大于0.7时可获得最佳敏感性/特异性。
