斯洛文尼亚水痘易感性和传播动力学。
Varicella susceptibility and transmission dynamics in Slovenia.
机构信息
Centre for Communicable Diseases, National Institute of Public Health of Republic of Slovenia, 1000 Ljubljana, Slovenia.
出版信息
BMC Public Health. 2010 Jun 23;10:360. doi: 10.1186/1471-2458-10-360.
BACKGROUND
A cross-sectional, age-stratified study was conducted to determine varicella-zoster seroprevalence and force of infection in Slovenia.
METHODS
3689 serum samples were tested for VZV IgG antibodies with an enzyme immunoassay. Semiparametric and parametric modelling were used to estimate the force of infection.
RESULTS
Overall, 85.6% of serum samples were seropositive. Age-specific prevalence rose rapidly in preschool children and over 90% of 8 years old tested positive for VZV. However, 2.8% of serum samples among women of childbearing age were seronegative. Semiparametric modelling yielded force of infection estimates of 0.182 (95% CI 0.158-0.206), 0.367 (95% CI 0.285-0.448) and 0.008 (95% CI 0.0-0.032) for age groups 0.5- < 6, 6-11 and >or=12 years, respectively, and 0.175 (95% CI 0.147-0.202), 0.391 (95% CI 0.303-0.480) and 0.025 (95% CI 0.003-0.046) for age groups 0.5- < 5, 5-9 and >or=10 years, respectively.
CONCLUSIONS
Regardless of the age grouping used, the highest transmission occurred in children in their first years of school.
背景
本横断面、年龄分层研究旨在确定斯洛文尼亚水痘带状疱疹血清流行率和感染率。
方法
采用酶联免疫吸附试验检测 3689 份血清样本的 VZV IgG 抗体。采用半参数和参数模型估计感染率。
结果
总体而言，85.6%的血清样本呈血清阳性。学龄前儿童的年龄特异性患病率迅速上升，超过 90%的 8 岁儿童 VZV 检测呈阳性。然而，育龄妇女中有 2.8%的血清样本呈血清阴性。半参数模型得出的感染率估计值分别为 0.182（95%CI 0.158-0.206）、0.367（95%CI 0.285-0.448）和 0.008（95%CI 0.0-0.032），年龄组为 0.5-<6 岁、6-11 岁和≥12 岁，0.175（95%CI 0.147-0.202）、0.391（95%CI 0.303-0.480）和 0.025（95%CI 0.003-0.046），年龄组为 0.5-<5 岁、5-9 岁和≥10 岁。
结论
无论使用哪种年龄分组，最高的传播都发生在儿童入学的头几年。
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