Erasmus MC Stem Cell Institute, Dept of Cell Biology, Erasmus University Medical Center Rotterdam, The Netherlands.
Trends Mol Med. 2010 Aug;16(8):361-7. doi: 10.1016/j.molmed.2010.05.005. Epub 2010 Jun 30.
The placenta is a large, highly vascularised hematopoietic tissue that functions during the embryonic and foetal development of eutherian mammals. Although recognised as the interface tissue important in the exchange of oxygen, nutrients and waste products between the foetus and mother, the placenta has increasingly become a focus of research concerning the ontogeny of the blood system. Here, we describe recent data showing the intrinsic hematopoietic potential and appearance of hematopoietic cells in the mouse and human placenta and probe the biological rationale behind its hematopoietic function. As a rest tissue that contains potent hematopoietic stem cells (HSCs), the human placenta could represent (in addition to umbilical cord blood cells) an accessible supplemental source of cells for therapeutic strategies.
胎盘是一种大型的、高度血管化的造血组织，在真兽类哺乳动物的胚胎和胎儿发育过程中发挥作用。尽管胎盘被认为是在胎儿和母亲之间进行氧气、营养物质和废物交换的重要界面组织，但它越来越成为研究血液系统发生的焦点。在这里，我们描述了最近的数据，这些数据显示了小鼠和人胎盘的固有造血潜力和造血细胞的出现，并探讨了其造血功能的生物学原理。作为一种含有造血干细胞（HSCs）的静止组织，人胎盘除了脐带血细胞之外，可能代表了一种可获得的补充细胞来源，用于治疗策略。
