Munir Muhammad, Linde Anna-Malin, Zohari Siamak, Ståhl Karl, Baule Claudia, Holm Kerstin, Engström Björn, Berg Mikael
Joint Research and Development Unit for Virology, Immunobiology and Parasitology of the National Veterinary Institute (SVA) and Swedish University of Agricultural Sciences (SLU), Department of Biomedical Sciences and Veterinary Public Health, Division of Microbiology and Food Safety, Ulls väg 2B, SE-751 89 Uppsala, Sweden.
Avian Dis. 2010 Jun;54(2):923-30. doi: 10.1637/9086-092409-RESNOTE.1.
The complete genome sequence of an avian paramyxovirus serotype 1 (APMV-1) isolated from a black-headed gull (Larus ridibundus) in Sweden was determined and compared with other APMV-1 sequences. Sequence analyses showed that this isolate consists of six genes in the order 3'-NP-P-M-F-HN-L-5', is 15,186 nucleotides long, and contains a typical, avirulent fusion protein cleavage site. It was also shown to have a hemagglutinin-neuraminidase protein with a length of 585 amino acids (aa) instead of the expected 616 aa. Phylogenetic analyses showed that the isolate belongs to genotype I, and the relationship with some other, known APMV-1 virus sequences was revealed. Waterfowl have been considered to act as a reservoir for APMV-1 and, therefore, it is important to broaden the knowledge of viruses circulating within this population.
测定了从瑞典一只黑头鸥（红嘴鸥）分离出的禽副粘病毒1型（APMV-1）的全基因组序列，并与其他APMV-1序列进行了比较。序列分析表明，该分离株由六个基因组成，顺序为3'-NP-P-M-F-HN-L-5'，长度为15186个核苷酸，含有典型的无毒融合蛋白切割位点。还显示其血凝素神经氨酸酶蛋白长度为585个氨基酸，而非预期的616个氨基酸。系统发育分析表明，该分离株属于基因型I，并揭示了其与其他一些已知APMV-1病毒序列的关系。水禽被认为是APMV-1的储存宿主，因此，拓宽对该种群中传播的病毒的认识很重要。
