Kwak Eun Soo, Just Allan, Whyatt Robin, Miller Rachel L
Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, USA.
Open Allergy J. 2009;2:45-50. doi: 10.2174/1874838400902010045.
Phthalates, pesticides, and bisphenol-A (BPA) are three groups of chemicals, implicated in endocrine disruption and commonly found in the local environment, that have been implicated in the pathogenesis of asthma and allergies [1-3]. Multiple observational studies have demonstrated an association between exposure to phthalates and the development of asthma and allergies in humans. Associations with exposure to pesticides and BPA and the development of respiratory disease are less clear. However, recent evidence suggests that prenatal or early postnatal exposure to BPA may be deleterious to the developing immune system. Future cohort-driven epidemiological or translational research should focus on determining whether these ubiquitous chemicals contribute to the development of asthma and allergies in humans, and attempt to establish the routes and mechanisms by which they operate. Determining dose-response relationships will be important to establishing safe levels of these chemicals in the environment and in consumer products. Attempts to reduce exposures to chemicals such as phthalates, pesticides, and BPA may have environmental repercussions as well as public health impact for the developing child.
邻苯二甲酸盐、农药和双酚A（BPA）是三类化学物质，与内分泌干扰有关，在当地环境中普遍存在，它们与哮喘和过敏的发病机制有关[1-3]。多项观察性研究表明，接触邻苯二甲酸盐与人类哮喘和过敏的发生之间存在关联。接触农药和双酚A与呼吸系统疾病发生之间的关联尚不清楚。然而，最近的证据表明，产前或产后早期接触双酚A可能对发育中的免疫系统有害。未来由队列驱动的流行病学或转化研究应侧重于确定这些普遍存在的化学物质是否会导致人类哮喘和过敏的发生，并试图确定它们起作用的途径和机制。确定剂量反应关系对于确定这些化学物质在环境和消费品中的安全水平至关重要。减少接触邻苯二甲酸盐、农药和双酚A等化学物质的尝试可能会对环境产生影响，同时也会对发育中的儿童产生公共卫生影响。
