Department of Ophthalmology, Poostchi Ophthalmology Research Center and Binagostar eye center, Shiraz University of Medical Sciences, Shiraz, Iran.
Cornea. 2010 Oct;29(10):1091-5. doi: 10.1097/ICO.0b013e3181cf98e5.
To assess the degrees of agreement in measuring corneal thickness in normal eyes between 2 noncontact systems based on the dual Scheimpflug system (Galilei; Ziemer) and rotating Scheimpflug imaging (HR Pentacam; Oculus) and also between each of these methods and the gold-standard method of ultrasound pachymetry.
In a prospective study, measurement agreement was assessed in 47 eyes of 47 healthy subjects. All eyes were examined with each of the 3 devices. Measurements made with the Galilei and HR Pentacam were compared with those made with ultrasound. The central corneal thickness (CCT) and thinnest pachymetry of the Galilei and HR Pentacam were also compared.
The mean values of CCT obtained from Galilei, HR Pentacam, and ultrasound were 560.57 ± 29.10, 542.31 ± 30.50, and 548.61 ± 29.92 μm, respectively. The 95% limits of agreement of each of these devices with ultrasound were -11.03 and +34.94 μm for the Galilei and -33.67 and +20.74 μm for the Pentacam. The 95% limits of agreement of Galilei with Pentacam in measurement of central and thinnest corneal thickness were -3.39 and +33.11 and -10.40 and +27.29 μm, respectively. Although CCT measurements made with the HR Pentacam were thinner (P < 0.001), and those obtained with Galilei were thicker (P < 0.001) than those made with ultrasound, there were significant correlation between Galilei and ultrasound (r = 0.92; P < 0.0001) and between HR Pentacam and ultrasound (r = 0.89; P < 0.0001). The central and thinnest corneal thickness measurements made with the HR Pentacam were thinner (P < 0.0001) than those made with Galilei, but there was a significant correlation between Galilei and HR Pentacam in measuring CCT (r = 0.96; P < 0.0001) and thinnest corneal thickness (r = 0.95; P < 0.0001). Bland-Altman plots showed good agreement between these methods.
Although differences between the devices were statistically significant, there was good correlation and agreement between Galilei and Pentacam in measuring central and thinnest corneal thickness. The corneal thickness measurements made with the HR Pentacam and Galilei also showed good correlation and agreement with those made with ultrasound.
评估两种基于双通道 Scheimpflug 系统（Galilei；Ziemer）和旋转 Scheimpflug 成像（HR Pentacam；Oculus）的非接触式系统在正常眼中测量角膜厚度的程度，并评估这两种方法与超声角膜测厚仪的金标准方法之间的测量一致性。
在一项前瞻性研究中，对 47 名健康受试者的 47 只眼进行了测量一致性评估。所有眼均接受了这 3 种设备的检查。将 Galilei 和 HR Pentacam 的测量值与超声测量值进行比较。还比较了 Galilei 和 HR Pentacam 的中央角膜厚度（CCT）和最薄角膜厚度。
Galilei、HR Pentacam 和超声分别获得的 CCT 平均值为 560.57 ± 29.10μm、542.31 ± 30.50μm 和 548.61 ± 29.92μm。这些设备与超声之间的 95%一致性界限分别为 Galilei 的-11.03μm 和+34.94μm，以及 Pentacam 的-33.67μm 和+20.74μm。Galilei 与 Pentacam 在中央和最薄角膜厚度测量中的 95%一致性界限分别为-3.39μm 和+33.11μm，以及-10.40μm 和+27.29μm。尽管 HR Pentacam 测量的 CCT 更薄（P<0.001），而 Galilei 测量的 CCT 更厚（P<0.001），但 Galilei 与超声之间存在显著相关性（r=0.92；P<0.0001），HR Pentacam 与超声之间也存在显著相关性（r=0.89；P<0.0001）。HR Pentacam 测量的中央和最薄角膜厚度均较 Galilei 更薄（P<0.0001），但 Galilei 与 HR Pentacam 在测量 CCT（r=0.96；P<0.0001）和最薄角膜厚度（r=0.95；P<0.0001）方面具有显著相关性。Bland-Altman 图显示这些方法之间具有良好的一致性。
尽管设备之间存在统计学差异，但 Galilei 和 Pentacam 在测量中央和最薄角膜厚度方面具有良好的相关性和一致性。HR Pentacam 和 Galilei 测量的角膜厚度也与超声测量的角膜厚度具有良好的相关性和一致性。
