Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.
Curr Opin Plant Biol. 2010 Oct;13(5):548-55. doi: 10.1016/j.pbi.2010.06.002. Epub 2010 Jul 16.
In development, pattern formation requires that cell proliferation and differentiation be precisely coordinated. Stomatal development has served as a useful model system for understanding how this is accomplished in plants. Although it has been known for some time that stomatal development is regulated by a family of receptor-like kinases (RLKs) and an accompanying receptor-like protein (RLP), only recently have putative ligands been identified. Despite the structural homology demonstrated by the genes that encode these small, secreted peptides, they convey different information, vary with one another in their relationship to common signaling components, control distinct aspects of stomatal development, and do so antagonistically. Their discovery has revealed the intricate network of interactions required upstream of RLK signal transduction for the patterning of complex tissues. However, at issue still is whether specific ligand-receptor combinations are responsible for the activation of discrete signaling pathways or spatiotemporal modulation of a common pathway. This review integrates the latest findings regarding RLK-mediated signaling in stomatal development with emerging paradigms in the field.
在发育过程中，模式形成要求细胞增殖和分化精确协调。气孔发育是一个理解植物如何实现这一目标的有用模型系统。尽管人们已经知道一段时间，气孔发育受一系列受体样激酶（RLKs）和伴随的受体样蛋白（RLP）调控，但最近才鉴定出假定的配体。尽管编码这些小分泌肽的基因表现出结构同源性，但它们传递不同的信息，彼此之间在与常见信号成分的关系、控制气孔发育的不同方面以及拮抗作用方面存在差异。它们的发现揭示了复杂组织模式形成所必需的上游 RLK 信号转导的复杂相互作用网络。然而，仍有争议的是，特定的配体-受体组合是否负责离散信号通路的激活，还是共同通路的时空调节。这篇综述将最新的关于 RLK 介导的气孔发育信号转导的发现与该领域新兴的范例结合起来。
