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突触和神经元回路的化学生物学。

The chemical biology of synapses and neuronal circuits.

机构信息

Department of Neurochemistry at University of Tokyo Graduate School of Medicine, Tokyo, Japan.

出版信息

Nat Chem Biol. 2010 Aug;6(8):560-3. doi: 10.1038/nchembio.408.

DOI:10.1038/nchembio.408
PMID:20644538
Abstract

Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have important biological consequences. Powerful chemical biological techniques have now been developed to decipher the dynamic stability of the synapses and to further interrogate the complex properties of neuronal circuits.

摘要

兴奋性突触位于称为树突棘的受限化学空间中。这些是典型的飞升级微域，即使单个分子的行为也可能产生重要的生物学后果。现在已经开发出强大的化学生物技术来破译突触的动态稳定性，并进一步研究神经元回路的复杂特性。

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