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生物 MOFs:用于生物和医学应用的金属有机骨架

BioMOFs: metal-organic frameworks for biological and medical applications.

机构信息

EaStChem School of Chemistry, University of St Andrews, Purdie Building, St Andrews, KY16 9ST UK.

出版信息

Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6260-6. doi: 10.1002/anie.201000048.

Abstract

The class of highly porous materials called metal-organic frameworks offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, and their high level of functionality enables possible applications as imaging agents and as delivery vehicles for therapeutic agents. The challenges in the area encompass not only the development of new solids but also improvements in the formulation and processing of the materials, including tailoring the morphology and surface chemistry of the frameworks to fit the proposed applications.

摘要

一类被称为金属-有机骨架的高多孔材料为生物学和医学的应用提供了很多机会。它们的化学成分范围很广,使得在毒理学上可接受的配方成为可能,而且它们的功能水平很高,可作为成像剂和治疗剂的输送载体。该领域的挑战不仅包括新型固体的开发,还包括改进材料的配方和加工,包括根据拟议应用来调整框架的形态和表面化学。

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