通过原位杂交将核糖体结合蛋白II（RPN II）基因定位于人类染色体20q12 - q13.1。
Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization.
作者信息
Löffler C, Rao V V, Hansmann I
机构信息
Institut für Humangenetik, Universität, Göttingen, Federal Republic of Germany.
出版信息
Hum Genet. 1991 Jun;87(2):221-2. doi: 10.1007/BF00204188.
Ribophorin I and II (RPN I and RPN II), two specific glycoproteins, span the rough regions of the endoplasmic reticulum (RER) and are thought to play an important role either in translocation or in the maintenance of RER. Studies with human-mouse somatic cell hybrids have localized the gene for RPN I on human chromosome 3q, while RPN II is on chromosome 20. Using a radioactive labelled cDNA probe, we have regionally mapped the RPN II gene to human chromosome 20q12-q13.1 by in situ hybridization. This assignment predicts a location of the murine homologue, Rpn-2, to the syntenic segment on mouse chromosome 2 in close proximity to Ada, Src and Gnas.
核糖体结合糖蛋白I和II（RPN I和RPN II）是两种特定的糖蛋白，横跨内质网（RER）的粗面区域，被认为在转运或内质网维持中发挥重要作用。对人-小鼠体细胞杂种的研究已将RPN I基因定位在人类3号染色体长臂上，而RPN II位于20号染色体上。我们使用放射性标记的cDNA探针，通过原位杂交将RPN II基因区域定位到人类20号染色体长臂12区至13.1区。这一定位预测小鼠同源物Rpn-2位于小鼠2号染色体上与Ada、Src和Gnas紧密相邻的同线区段。
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