绿茶多酚防治头颈部癌症。
Chemoprevention of head and neck cancer with green tea polyphenols.
机构信息
Emory University, Atlanta, GA 30322, USA.
出版信息
Cancer Prev Res (Phila). 2010 Aug;3(8):900-9. doi: 10.1158/1940-6207.CAPR-09-0131. Epub 2010 Jul 27.
Abstract
Recently, squamous cell carcinoma of the head and neck chemoprevention research has made major advances with novel clinical trial designs suited for the purpose, use of biomarkers to identify high-risk patients, and the emergence of numerous molecularly targeted agents and natural dietary compounds. Among many natural compounds, green tea polyphenols, particularly (-)-epigallocatechin-3-gallate (EGCG), possess remarkable potential as chemopreventive agents. EGCG modulates several key molecular signaling pathways at multiple levels and has synergistic or additive effects when combined with many other natural or synthetic compounds. This review will provide an update of the potential of green tea polyphenols, particularly EGCG, for the chemoprevention of squamous cell carcinoma of the head and neck.
摘要
最近，头颈部鳞状细胞癌的化学预防研究取得了重大进展，出现了适合该目的的新型临床试验设计、用于识别高危患者的生物标志物以及众多分子靶向药物和天然膳食化合物。在众多天然化合物中，绿茶多酚，特别是（-）-表没食子儿茶素-3-没食子酸酯（EGCG），具有作为化学预防剂的显著潜力。EGCG 在多个水平上调节几个关键的分子信号通路，并且与许多其他天然或合成化合物联合使用时具有协同或相加作用。本文将综述绿茶多酚，特别是 EGCG，对头颈部鳞状细胞癌化学预防的潜在作用。
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