Rugman F P, Pinn G, Palmer M F, Waite M, Hay C R
University Department of Haematology, Royal Liverpool Hospital.
J Clin Pathol. 1991 Jun;44(6):517-9. doi: 10.1136/jcp.44.6.517.
The clinical course and serology of 16 cases of leptospirosis in an area with an unusually high endemic infection rate were studied to gain further insight into the pathology of the secondary immune phase that is typical of the disease. IgG anticardiolipin antibody concentrations were measured by immunoassay and found to be increased in eight serologically confirmed cases with severe complicated disease, compared with eight patients with relatively uncomplicated leptospirosis who had IgG anticardiolipin concentrations within the control reference range. This previously unreported association suggests that leptospira may induce vascular endothelial injury in severe cases and expose crypt antigens or induce conformational change of cell surface phospholipids. Leptospirosis may provide a model for an infective origin of some cases of the antiphospholipid syndrome.
在一个地方感染率异常高的地区，对16例钩端螺旋体病患者的临床病程和血清学进行了研究，以进一步了解该病典型的继发性免疫阶段的病理情况。通过免疫测定法检测了IgG抗心磷脂抗体浓度，发现与8例相对未出现并发症的钩端螺旋体病患者相比，8例血清学确诊的重症并发症患者的该抗体浓度升高，后一组患者的IgG抗心磷脂浓度在对照参考范围内。这种此前未报告过的关联表明，钩端螺旋体在严重病例中可能会导致血管内皮损伤，并暴露隐蔽抗原或诱导细胞表面磷脂的构象变化。钩端螺旋体病可能为某些抗磷脂综合征病例的感染性病因提供一个模型。
