Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
Opt Lett. 2010 Jan 1;35(1):1-3. doi: 10.1364/OL.35.000001.
We present label-free functional photoacoustic imaging of the ocular microvasculature in living animals. The anterior segment of an adult mouse was imaged with a laser exposure level well within the American National Standards Institute safety standards. Individual red blood cells traveling along the iris capillaries were clearly resolved, and the hemoglobin oxygen saturation in the iris microvasculature was imaged spectrally. We believe that photoacoustic imaging has the potential to advance the diagnosis and treatment of ocular diseases in humans.
我们提出了一种无标记的活体动物眼部微血管功能光声成像方法。使用的激光辐照强度远低于美国国家标准协会的安全标准，对成年小鼠的眼前节进行了成像。清晰地分辨出沿虹膜毛细血管流动的单个红细胞，并且对虹膜微血管中的血红蛋白氧饱和度进行了光谱成像。我们相信光声成像是有潜力用于推进人类眼部疾病的诊断和治疗的。
