Lim Ji Won, Cho Joon Hee, Kim Ha Kyoung
Department of Ophthalmology, Hallym University Sacred Heart Hospital, Chuncheon, Republic of Korea.
Clin Ophthalmol. 2010 Jul 30;4:689-94. doi: 10.2147/opth.s12042.
The aim of the current study was to evaluate macular function before and after surgery for idiopathic epiretinal membranes with internal limiting membrane (ILM) peeling by means of multifocal electroretinography (ERG). Eighteen eyes of 18 patients who underwent vitrectomy with ILM removal were included. Best corrected visual acuity, optical coherence tomography (OCT), and multifocal electroretinography were assessed prior to surgery, and 3 and 12 months after surgery. All surgical samples were obtained and confirmed inclusion of an ILM by electron microscopy. Visual acuity and the central foveal thickness by OCT improved significantly 3 months postoperatively, with gradual recovery by 12 months. Preoperatively, only the P1 amplitude in rings 1 and 2 were decreased compared with the normal fellow eyes (P < 0.01). Three and 12 months after surgery, the P1 amplitude in rings 1 and 2 were decreased compared with the preoperative P1 amplitudes, but without significance. The photoreceptor status by OCT was related to the N1 amplitude before and after surgery. Although visual acuity and macular edema were improved after surgery, macular function, as indicated by multifocal ERG, had limited recovery at 12 months.
本研究的目的是通过多焦视网膜电图（ERG）评估特发性视网膜前膜伴内界膜（ILM）剥除手术前后的黄斑功能。纳入18例行ILM切除玻璃体切除术患者的18只眼。在手术前、术后3个月和12个月评估最佳矫正视力、光学相干断层扫描（OCT）和多焦视网膜电图。获取所有手术标本并通过电子显微镜确认包含ILM。术后3个月，视力和OCT测量的中心凹厚度显著改善，至12个月逐渐恢复。术前，与对侧正常眼相比，仅环1和环2中的P1波幅降低（P<0.01）。术后3个月和12个月，环1和环2中的P1波幅与术前P1波幅相比降低，但无统计学意义。OCT显示的光感受器状态与手术前后的N1波幅相关。尽管术后视力和黄斑水肿有所改善，但多焦ERG显示黄斑功能在12个月时恢复有限。
