Division of Materials Design, Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507 Warsaw, Poland.
J Biomed Mater Res B Appl Biomater. 2010 Oct;95(1):53-61. doi: 10.1002/jbm.b.31682.
For many years, the solid metals and their alloys have been widely used for fabrication of the implants replacing hard human tissues or their functions. To improve fixation of solid implants to the surrounding bone tissues, the materials with porous structures have been introduced. By tissue ingrowing into a porous structure of metallic implant, the bonding between the implant and the bone has been obtained. Substantial pore interconnectivity, in metallic implants, allows extensive body fluid transport through the porous implant. This can provoke bone tissue ingrowth, consequently, leading to the development of highly porous metallic implants, which could be used as scaffolds in bone tissue engineering. The goal of this study was to develop and then investigate properties of highly porous titanium structures received from powder metallurgy process. The properties of porous titanium samples, such as microstructure, porosity, Young's modulus, strength, together with permeability and corrosion resistance were investigated. Porous titanium scaffolds with nonhomogeneous distribution of interconnected pores with pore size in the range up to 600 μm in diameter and a total porosity in the range up to 75% were developed. The relatively high permeability was observed for samples with highest values of porosity. Comparing to cast titanium, the porous titanium was low resistant to corrosion. The mechanical parameters of the investigated samples were similar to those for cancellous bone. The development of high-porous titanium material shows high potential to be modern material for creating a 3D structure for bone regeneration and implant fixation.
多年来，固体金属及其合金已广泛用于制造替代硬组织或其功能的植入物。为了提高固体植入物与周围骨组织的固定，引入了具有多孔结构的材料。通过组织长入金属植入物的多孔结构，获得了植入物与骨之间的结合。在金属植入物中，大量的孔连通性允许大量的体液通过多孔植入物运输。这可以引发骨组织的长入，从而导致高多孔金属植入物的发展，这些植入物可以用作骨组织工程中的支架。本研究的目的是开发粉末冶金工艺获得的高多孔钛结构，并研究其性能。研究了多孔钛样品的性能，如微观结构、孔隙率、杨氏模量、强度以及渗透性和耐腐蚀性。开发了具有非均匀分布的相互连通的孔的多孔钛支架，孔径范围高达 600μm，总孔隙率高达 75%。具有最高孔隙率的样品表现出相对较高的渗透性。与铸造钛相比，多孔钛的耐腐蚀性较低。所研究样品的机械参数与松质骨相似。高多孔钛材料的开发显示出在创造用于骨再生和植入物固定的 3D 结构方面成为现代材料的巨大潜力。
