School of Paediatrics and Child Health, University of Western Australia, Perth WA 6840, Australia.
Eur Respir J. 2011 May;37(5):1037-42. doi: 10.1183/09031936.00092410. Epub 2010 Aug 6.
A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and cause more severe attacks than other viruses or HRV groups. Children with acute asthma (n = 128; age 2-16 yrs) were recruited on presentation to an emergency department. Asthma exacerbation severity was assessed, and respiratory viruses and HRV strains were identified in a nasal aspirate. The majority of the children studied had moderate-to-severe asthma (85.2%) and 98.9% were admitted to hospital. HRV was detected in 87.5% and other respiratory viruses in 14.8% of children, most of whom also had HRV. HRVC was present in the majority of children with acute asthma (59.4%) and associated with more severe asthma. Children with HRVC (n = 76) had higher asthma severity scores than children whose HRV infection was HRVA or HRVB only (n = 34; p = 0.018), and all other children (n = 50; p = 0.016). Of the 19 children with a non-HRV virus, 13 had HRV co-infections, seven of these being HRVC. HRVC accounts for the majority of asthma attacks in children presenting to hospital and causes more severe attacks than previously known HRV groups and other viruses.
一种新的、可能具有更高致病性的人类鼻病毒（HRV）组 C（HRVC）最近被发现。我们假设 HRVC 会存在于患有急性哮喘的儿童中，并导致比其他病毒或 HRV 组更严重的发作。在急诊室就诊时招募了患有急性哮喘的儿童（n = 128；年龄 2-16 岁）。评估哮喘加重的严重程度，并在鼻抽吸物中鉴定呼吸道病毒和 HRV 株。研究的大多数儿童患有中重度哮喘（85.2%），98.9%的儿童住院。在 87.5%的儿童中检测到 HRV，在 14.8%的儿童中检测到其他呼吸道病毒，其中大多数也有 HRV。HRVC 存在于大多数患有急性哮喘的儿童（59.4%）中，且与更严重的哮喘有关。患有 HRVC（n = 76）的儿童的哮喘严重程度评分高于仅感染 HRVA 或 HRVB 的 HRV 感染儿童（n = 34；p = 0.018），也高于所有其他儿童（n = 50；p = 0.016）。在 19 名患有非 HRV 病毒的儿童中，有 13 名儿童存在 HRV 合并感染，其中 7 名是 HRVC。HRVC 占就诊于医院的儿童哮喘发作的大多数，并且比以前已知的 HRV 组和其他病毒引起更严重的发作。
