万古霉素、青霉素和庆大霉素联合使用对A、B和C类耐万古霉素肠球菌的协同杀灭作用。
Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin.
作者信息
Shlaes D M, Etter L, Gutmann L
机构信息
Infectious Diseases Section, Department of Veterans Affairs Medical Center, Cleveland, Ohio.
出版信息
Antimicrob Agents Chemother. 1991 Apr;35(4):776-9. doi: 10.1128/AAC.35.4.776.
Abstract
Using both high and low inocula for time-kill curves, we examined the antibiotic killing of clinical isolates of glycopeptide-resistant enterococci (Enterococcus faecium, E. faecalis, and E. gallinarum) belonging to phenotypic resistance classes A, B, and C. None were resistant to high levels (greater than 500 mg/liter) of gentamicin. Vancomycin-penicillin-gentamicin resulted in 2 or more logs of killing above that of the most effective two-antibiotic combination for all strains except two of three E. gallinarum (VanC) strains and a constitutive mutant of a VanB strain. This strategy may be useful clinically.
摘要
我们使用高接种量和低接种量绘制时间-杀菌曲线，检测了属于A、B和C表型耐药类别的耐糖肽肠球菌（屎肠球菌、粪肠球菌和鹑鸡肠球菌）临床分离株的抗生素杀菌情况。所有菌株对高水平（大于500毫克/升）庆大霉素均不耐药。除3株鹑鸡肠球菌（VanC）中的2株以及1株VanB菌株的组成型突变体之外，万古霉素-青霉素-庆大霉素对所有菌株的杀菌效果比最有效的两种抗生素联合用药高出2个或更多对数。该策略在临床上可能有用。
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