E(x)ponent®, Inc., Washington, DC 20036, USA.
Food Chem Toxicol. 2010 Nov;48(11):3098-108. doi: 10.1016/j.fct.2010.08.003. Epub 2010 Aug 7.
The objective of this study is to evaluate the relationship between dietary AA and hemoglobin adducts using the National Health and Nutrition Examination Survey (NHANES, 2003-04). Measured acrylamide (AA-Hb) and glycidamide (Gly-Hb) hemoglobin adducts for over 7000 participants >3 years, 24-h dietary recall, food frequency questionnaire (FFQ), lifestyle and demographic data, and anthropometric measurements are available from NHANES (2003-04). The 24-h dietary recall and FFQ data were combined with AA concentration data in food from the US FDA to estimate "usual" AA dietary exposure. The associations between dietary AA and AA-Hb and Gly-Hb were evaluated using linear regression models with smoking, age, gender, energy and macronutrient intake, body surface area, and activity level as covariates. Dietary AA positively correlates with AA-Hb and Gly-Hb (p<0.05) but the correlation is small (R-Squared<3.5%). Relative to the background adduct levels, the incremental increase in AA-Hb and Gly-Hb from average dietary AA is small (7% and 9% for AA-Hb and Gly-Hb, respectively). Non-dietary sources of exposure, measurement errors associated with the use of the FFQ, and uncertainty in the data on AA levels in foods are possible explanations for the observed lack of association between dietary AA and AA-Hb and Gly-Hb.
本研究旨在利用美国国家健康与营养调查（NHANES，2003-04 年）评估膳食 AA 与血红蛋白加合物之间的关系。对超过 7000 名年龄大于 3 岁的参与者进行了丙烯酰胺（AA-Hb）和缩水甘油（Gly-Hb）血红蛋白加合物的测量，可获得 24 小时膳食回顾、食物频率问卷（FFQ）、生活方式和人口统计学数据以及人体测量学数据。NHANES（2003-04 年）提供了 24 小时膳食回顾和 FFQ 数据，并与美国 FDA 食品中的 AA 浓度数据相结合，以估计“通常”的 AA 膳食暴露量。采用线性回归模型，以吸烟、年龄、性别、能量和宏量营养素摄入、体表面积和活动水平为协变量，评估膳食 AA 与 AA-Hb 和 Gly-Hb 之间的关联。膳食 AA 与 AA-Hb 和 Gly-Hb 呈正相关（p<0.05），但相关性较小（R 平方<3.5%）。与背景加合物水平相比，AA-Hb 和 Gly-Hb 中平均膳食 AA 的增量增加很小（分别为 AA-Hb 和 Gly-Hb 的 7%和 9%）。非膳食暴露源、FFQ 使用相关的测量误差以及食物中 AA 水平数据的不确定性，可能是观察到膳食 AA 与 AA-Hb 和 Gly-Hb 之间缺乏关联的原因。
