Department of Kinesiology, University of Texas at El Paso, El Paso, Texas 79902, USA.
Endocr Res. 2010;35(3):106-17. doi: 10.3109/07435800.2010.496090.
The purpose of this study was to examine the relationship between fasting serum leptin and adiponectin levels with bone mineral density (BMD) and body composition in pre-menopausal, middle-aged Hispanic and Caucasian women.
Participants' (68 Hispanic and 36 Caucasian) BMD and bone mineral content were measured by dual-energy X-ray absorptiometry, and body density was measured by hydrodensitometry. Serum leptin was determined by enzyme immunoassay and adiponectin by ELISA.
Hispanic women had significantly higher leptin, BMD, and fat mass (FM), and lower adiponectin than Caucasian women. There was no significant correlation between leptin and BMD for Hispanic or Caucasian women; adiponectin was inversely correlated with BMD in Caucasian women only (p = 0.01). In both Hispanic and Caucasian women, lean body mass and adiponectin best explained the variance in BMD (r(2) = 0.25, p < 0.001).
These data demonstrate no significant relationship between leptin and BMD of pre-menopausal, middle-aged Hispanic and Caucasian women, and a significant inverse relationship between adiponectin and BMD in Caucasian women. The role of adipocytokines in the regulation of BMD remains inconclusive and may vary across ethnic groups.
本研究旨在探讨绝经前、中年西班牙裔和白种女性空腹血清瘦素和脂联素水平与骨密度（BMD）和身体成分的关系。
采用双能 X 射线吸收法测定研究对象（68 名西班牙裔和 36 名白种人）的 BMD 和骨矿物质含量，采用比重瓶法测定体密度。采用酶联免疫吸附法测定血清瘦素，采用 ELISA 法测定脂联素。
西班牙裔女性的瘦素、BMD 和脂肪量（FM）显著高于白种女性，脂联素水平显著低于白种女性。西班牙裔或白种女性的瘦素与 BMD 之间均无显著相关性；只有白种女性的脂联素与 BMD 呈负相关（p = 0.01）。在西班牙裔和白种女性中，瘦体重和脂联素能最好地解释 BMD 的差异（r²=0.25，p<0.001）。
这些数据表明，绝经前、中年西班牙裔和白种女性的瘦素与 BMD 之间无显著关系，白种女性的脂联素与 BMD 呈显著负相关。脂肪细胞因子在 BMD 调节中的作用尚不确定，并且可能因种族群体而异。
