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评估一种市售的用于空间分割放射治疗的挡块。

Evaluation of a commercially-available block for spatially fractionated radiation therapy.

机构信息

Departments of Radiology and Radiation Oncology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

出版信息

J Appl Clin Med Phys. 2010 Apr 26;11(3):3163. doi: 10.1120/jacmp.v11i3.3163.

Abstract

In this paper, we present the dosimetric characteristics of a commercially-produced universal GRID block for spatially fractioned radiation therapy. The dosimetric properties of the GRID block were evaluated. Ionization chamber and film measurements using both Kodak EDR2 and Gafchromic EBT film were performed in a solid water phantom to determine the relative output of the GRID block as well as its spatial dosimetric characteristics. The surface dose under the block and at the openings was measured using ultra thin TLDs. After introducing the GRID block into the treatment planning system, a treatment plan was created using the GRID block and also by creating a GRID pattern using the multi-leaf collimator. The percent depth doses measured with film showed that there is a shift of the dmax towards shallower depths for both energies (6 MV and 18 MV) under investigation. It was observed that the skin dose at the GRID openings was higher than the corresponding open field by a factor as high as 50% for both photon energies. The profiles showed the transmission under the block was in the order of 15-20% for 6 MV and 30% for 18 MV. The MUs calculated for a real patient using the block were about 80% less than the corresponding MUs for the same plan using the multileaf collimator to define the GRID. Based on this investigation, this brass GRID compensator is a viable alternative to other solid compensators or MLC-based fields currently in use. Its ease of creation and use give it decided advantages. Its ability to be created once and used for multiple patients (by varying the collimation of the linear accelerator jaws) makes it attractive from a cost perspective. We believe this compensator can be put to clinical use, and will allow more centers to offer GRID therapy to their patients.

摘要

在本文中,我们介绍了一种商用通用栅格块在分次放射治疗中的剂量学特性。评估了栅格块的剂量学特性。在固体水体模中使用电离室和胶片对柯达 EDR2 和 Gafchromic EBT 胶片进行了测量,以确定栅格块的相对输出以及其空间剂量学特性。使用超薄 TLD 测量了块下和开口处的表面剂量。在将栅格块引入治疗计划系统后,使用栅格块创建了治疗计划,并使用多叶准直器创建了栅格图案。使用胶片测量的百分深度剂量表明,对于两种能量(6 MV 和 18 MV),dmax 向较浅的深度转移。观察到栅格开口处的皮肤剂量比相应的开放场高出 50%,两种光子能量均如此。轮廓显示,对于 6 MV,块下的传输率约为 15-20%,对于 18 MV,传输率约为 30%。使用该块为实际患者计算的 MU 比使用多叶准直器定义栅格的相同计划少约 80%。基于此项研究,这种黄铜栅格补偿器是当前使用的其他固体补偿器或基于 MLC 的场的可行替代方案。它易于创建和使用,具有明显的优势。它可以一次创建并用于多个患者(通过改变直线加速器的准直器),从成本角度来看具有吸引力。我们相信这种补偿器可以投入临床使用,并将使更多的中心能够为其患者提供栅格治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcec/5720442/9f5636dc770a/ACM2-11-002-g001.jpg

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