National Office for Cancer Prevention and Control, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, No. 17 Panjiayuannanli, Chaoyang District, Beijing, 100021, China.
Breast Cancer Res Treat. 2011 Apr;126(2):515-20. doi: 10.1007/s10549-010-1128-0. Epub 2010 Aug 26.
Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between HPV infection and risk of breast carcinoma, the studies remain inconclusive. Here, a meta-analysis was conducted to estimate the prevalence of HPV in breast carcinoma and test the association. Studies on HPV DNA detection in sporadic breast carcinoma in female using polymerase chain reaction were included. Information on overall and type-specific (HPV 6, 11, 16, 18, 31, 33, 35, 45 and 51) HPV prevalence were required, plus detailed descriptions of study populations, HPV DNA source, publication calendar period and PCR primers used for HPV DNA detection and typing. We revealed that 24.49% of the breast carcinoma cases were associated with HPV, 32.42% occurred in Asia and 12.91% in Europe. The four most commonly identified HPV types, in the order of decreased prevalence, were HPV33, 18, 16, and 35. The detection of HPV was mostly influenced by publication calendar period and PCR primers used. In addition, the analysis of ten case-control studies containing 447 breast carcinoma cases and 275 controls showed a significant increase in breast carcinoma risk with HPV positivity (OR = 3.63, 95% CI = 1.42-9.27). These results suggest that it's difficult to rule out the possibility of the association of HPV and breast carcinoma at present according to available publication proofs.
尽管近年来进行了大量的分子流行病学研究来评估 HPV 感染与乳腺癌风险之间的关联，但这些研究仍然没有定论。在这里，我们进行了一项荟萃分析，以估计 HPV 在乳腺癌中的流行率，并检验其相关性。纳入了使用聚合酶链反应检测女性散发性乳腺癌中 HPV DNA 的研究。需要提供关于 HPV 总流行率和型特异性（HPV 6、11、16、18、31、33、35、45 和 51）的信息，以及研究人群、HPV DNA 来源、出版物时间跨度和用于 HPV DNA 检测和分型的 PCR 引物的详细描述。我们发现，24.49%的乳腺癌病例与 HPV 相关，32.42%发生在亚洲，12.91%发生在欧洲。最常见的四种 HPV 类型依次为 HPV33、18、16 和 35。HPV 的检测主要受到出版物时间跨度和使用的 PCR 引物的影响。此外，对包含 447 例乳腺癌病例和 275 例对照的 10 项病例对照研究的分析显示，HPV 阳性与乳腺癌风险显著增加（OR=3.63，95%CI=1.42-9.27）。这些结果表明，根据现有文献证据，目前很难排除 HPV 与乳腺癌之间存在关联的可能性。
