Sherwin S A, Rapp U R, Benveniste R E, Sen A, Todaro G J
J Virol. 1978 May;26(2):257-64. doi: 10.1128/JVI.26.2.257-264.1978.
Mus musculus SC-1 cells were infected with M7 baboon type C virus. The progeny of this infection included viral pseudotypes that contained M7 helper virus and endogenous 30S retrovirus-associated sequences derived from SC-1 cells (RAS). The RAS sequences are unrelated by nucleic acid hybridization criteria to previously described types of murine retroviruses and do not code for known murine viral structural proteins. The RAS genome is present in multiple copies in the DNA of laboratory (M. musculus) and Asian (M. caroli and M. cervicolor) mice, is expressed in the RNA of uninfected mouse cells, and can be efficiently rescued by type C, but not type B, viruses. RAS is closely related to 30S virus-associated RNA in NIH/3T3 and BALB/c JLSV-9 cells and may be analogous to the defective 30S RNA sequences found in rats.
小家鼠SC - 1细胞被狒狒M7型C病毒感染。此次感染的子代包括病毒假型，其包含M7辅助病毒以及源自SC - 1细胞（RAS）的内源性30S逆转录病毒相关序列。根据核酸杂交标准，RAS序列与先前描述的鼠类逆转录病毒类型无关，并且不编码已知的鼠类病毒结构蛋白。RAS基因组以多拷贝形式存在于实验室小鼠（小家鼠）和亚洲小鼠（卡罗小家鼠和姬小鼠）的DNA中，在未感染的小鼠细胞RNA中表达，并且可以被C型病毒有效拯救，但不能被B型病毒拯救。RAS与NIH/3T3和BALB/c JLSV - 9细胞中的30S病毒相关RNA密切相关，并且可能类似于在大鼠中发现的缺陷性30S RNA序列。
