Deshpande V, Verma K
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Cytopathology. 1998 Oct;9(5):329-35. doi: 10.1046/j.1365-2303.1998.00101.x.
Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy (SHML)) is a benign self-limiting disorder that commonly involves the lymph nodes. We reviewed eight cases of this entity aiming to document the cytomorphological features. Of the eight cases, a preoperative diagnosis was suggested in seven cases. Pertinent features included: numerous large histiocytes with prominent emperipolesis (documented by a halo around the cell), fine vacuoles in the cytoplasm and lymphocytes and plasma cells in the background. In some cases the histiocytes showed atypia. In one biopsy-proven case a diagnosis of Hodgkin's was suggested, emphasizing the pitfalls associated with the FNA diagnosis of this lesion.
罗萨伊-多夫曼病（伴巨大淋巴结病的窦组织细胞增生症，SHML）是一种通常累及淋巴结的良性自限性疾病。我们回顾了8例该疾病，旨在记录其细胞形态学特征。8例中，7例术前做出了诊断。相关特征包括：大量大组织细胞，可见明显的胞质吞噬现象（细胞周围有晕圈证明），细胞质内有细小空泡，背景中有淋巴细胞和浆细胞。部分病例中组织细胞表现出非典型性。在1例经活检证实的病例中曾误诊为霍奇金病，强调了该病变细针穿刺抽吸活检诊断中存在的陷阱。
