Aging and Dementia Imaging Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Alzheimers Res Ther. 2010 Aug 31;2(4):23. doi: 10.1186/alzrt47.
Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.
结构磁共振成像 (sMRI) 测量的萎缩是阿尔茨海默病 (AD) 神经退行性病理阶段和严重程度的有力生物标志物。在这篇综述中，我们将通过总结 (a) 从 sMRI 图像中提取信息的最常用方法，(b) sMRI 作为 AD 生物标志物的不同作用，以及 (c) sMRI 与其他主要 AD 生物标志物的比较，来讨论 sMRI 作为 AD 生物标志物的作用。
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