来自菲律宾大鼠的 46 株钩端螺旋体对 14 种抗菌药物的体外敏感性和耐药性。
In vitro sensitivity and resistance of 46 Leptospira strains isolated from rats in the Philippines to 14 antimicrobial agents.
机构信息
Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
出版信息
Antimicrob Agents Chemother. 2010 Dec;54(12):5403-5. doi: 10.1128/AAC.00973-10. Epub 2010 Sep 20.
Abstract
The in vitro susceptibilities of 46 Leptospira isolates from rats to 14 antimicrobial agents were tested. All of the strains were found to be sensitive to ampicillin, cefotaxime, ciprofloxacin, norfloxacin, doxycycline, erythromycin, and streptomycin. In contrast, the tested isolates showed resistance to amphotericin B, 5-fluorouracil, fosfomycin, trimethoprim, sulfamethoxazole, neomycin, and vancomycin. These findings will help in selecting effective and ineffective antimicrobials for treatment of leptospirosis and for the development of new selective media, respectively.
摘要
对 46 株来自大鼠的钩端螺旋体分离株进行了 14 种抗菌药物的体外药敏试验。所有菌株均对氨苄西林、头孢噻肟、环丙沙星、诺氟沙星、强力霉素、红霉素和链霉素敏感。相比之下，所测试的分离株对两性霉素 B、5-氟尿嘧啶、磷霉素、甲氧苄啶、磺胺甲噁唑、新霉素和万古霉素表现出耐药性。这些发现将有助于分别选择治疗钩端螺旋体病的有效和无效抗菌药物，并开发新的选择性培养基。
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