Venice Research Consortium, c/o VEGA - Venice Gateway for Science and Technology, Venice, Italy.
Nanotoxicology. 2011 Sep;5(3):445-58. doi: 10.3109/17435390.2010.512986. Epub 2010 Sep 23.
In assessing hazard for human health posed by newly engineered nanomaterials (ENM), approaches such as Weight of Evidence (WOE) and expert judgment are required to develop conclusions about the hazard of ENM. This is because all factors affecting hazard are not currently well defined and are often subject to different interpretation. Here we report the application of a WOE procedure to assess the potential of ENM to cause harm for human health, by integrating and combining physicochemical properties of NM and toxicity data obtained within the EU-funded Particle Risk project. The procedure was applied to carbon black (CB), single-walled carbon nanotubes (SWNT), C60 fullerene and quantum dots (QD) ENM tested during the Particle Risk project. The results show that some of the investigated ENM present a relatively higher hazardousness level on the basis of the integration of their physicochemical properties and toxicological effects, and that their hazard may be ranked as follow: QD >> C60 > SWNT > CB. This case study shows the utility of WOE approach to obtain a hazard ranking of ENM.
在评估新型工程纳米材料 (ENM) 对人类健康构成的危害时，需要采用证据权重 (WOE) 和专家判断等方法来得出关于 ENM 危害的结论。这是因为目前并非所有影响危害的因素都得到了很好的定义，而且这些因素常常受到不同的解释。在这里，我们报告了一种 WOE 程序的应用，该程序通过整合和结合欧盟资助的粒子风险项目中获得的 NM 的物理化学特性和毒性数据，来评估 ENM 对人类健康造成伤害的潜力。该程序应用于在粒子风险项目中测试的炭黑 (CB)、单壁碳纳米管 (SWNT)、C60 富勒烯和量子点 (QD) ENM。结果表明，根据其物理化学特性和毒理学效应的综合评估，一些研究中的 ENM 具有相对较高的危害性水平，并且它们的危害可能被列为如下：QD>>C60>SWNT>CB。该案例研究表明 WOE 方法在获得 ENM 的危害排名方面的实用性。
