National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), 20 Park Crescent, London, UK.
J Neurosci Methods. 2010 Nov 30;193(2):167-88. doi: 10.1016/j.jneumeth.2010.09.003. Epub 2010 Sep 22.
This report provides practical guidance on refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research. The guidance is based on consideration of the scientific literature and, where data are lacking, expert opinion and professional experience, including that of the members of a Working Group convened by the United Kingdom National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). The report should be useful to researchers, veterinarians and animal care staff responsible for the welfare of macaques used in food and fluid control protocols, as well as those involved with designing, performing and analysing studies that use these protocols. It should also assist regulatory authorities and members of local ethical review processes or institutional animal care and use committees concerned with evaluating such protocols. The report provides a framework for refinement that can be tailored to meet local requirements. It also identifies data gaps and areas for future research and sets out the Working Group's recommendations on contemporary best practice.
本报告就如何改进食物和水分控制的使用方法，为行为神经科学研究中使用的猕猴提供了实用指南。该指南基于对科学文献的考虑，在缺乏数据的情况下，还参考了专家意见和专业经验，包括英国国家实验动物替代、改进和减少中心（NC3Rs）召集的一个工作组的成员的经验。该报告应有助于负责食物和水分控制方案中猕猴福利的研究人员、兽医和动物饲养人员，以及参与设计、实施和分析使用这些方案的研究的人员。它还应有助于监管机构以及负责评估此类方案的地方伦理审查过程或机构动物护理和使用委员会的成员。该报告提供了一个可以根据当地要求进行定制的改进框架。它还确定了数据空白和未来研究领域，并就当代最佳实践提出了工作组的建议。
