Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Clin Immunol. 2010 Dec;137(3):406-14. doi: 10.1016/j.clim.2010.09.001. Epub 2010 Sep 29.
Dendritic cells (DC) are potent initiators of immune responses, compared to other professional antigen-presenting cells, based on their ability to capture antigen, express high amounts of MHC and co-stimulatory molecules, and to secrete immunostimulatory cytokines. Altered functions of DC in atopic individuals have been observed, though it is not clear if this is a cause or a result of the development of allergic disease. In this report we demonstrate altered cytokine production by DC isolated from infants with atopic dermatitis but without a diagnosis of asthma, compared to infants with non-atopic dermatitis. Increased production of IL-6, IL-10 and IFNα from DC isolated from atopic infants is less apparent when DC from infants were examined 1 year later. An increase in the same cytokines was observed in neonatal mice that are genetically predisposed towards allergic inflammation. These results suggest that an atopic environment promotes altered cytokine production by DC from infants.
树突状细胞（DC）是免疫反应的有力启动者，与其他专业抗原呈递细胞相比，基于其捕获抗原的能力、表达高水平 MHC 和共刺激分子的能力以及分泌免疫刺激性细胞因子的能力。在特应性个体中观察到 DC 的功能改变，但尚不清楚这是过敏疾病发展的原因还是结果。在本报告中，我们证明了与非特应性皮炎的婴儿相比，来自特应性皮炎婴儿的 DC 产生细胞因子的能力发生了改变。当检查 1 年后婴儿的 DC 时，来自特应性婴儿的 DC 产生的 IL-6、IL-10 和 IFNα 的产量增加不那么明显。在易患过敏炎症的遗传倾向的新生小鼠中观察到相同细胞因子的增加。这些结果表明，特应性环境促进了婴儿 DC 产生细胞因子的改变。
