J Cosmet Dermatol. 2010 Sep;9(3):246-8. doi: 10.1111/j.1473-2165.2010.00513.x.
Chemical peeling with both alpha and beta hydroxy acids has been used to improve acne scarring with pigmentation. Lactic acid, a mild alpha hydroxy acid, has been used in the treatment of various dermatological indications but no study is reported in acne scarring with pigmentation.
To evaluate the efficacy and safety of full strength pure lactic acid 92% (pH 2.0) chemical peel in superficial acne scarring in Indian skin.
Seven patients, Fitzpatrick skin type IV-V, in age group 20-30 years with superficial acne scarring were enrolled in the study. Chemical peeling was done with lactic acid at an interval of 2 weeks to a maximum of four peels. Pre- and post-peel clinical photographs were taken at every session. Patients were followed every month for 3 months after the last peel to evaluate the effects.
At the end of 3 months, there was definite improvement in the texture, pigmentation, and appearance of the treated skin, with lightening of scars. Significant improvement (greater than 75% clearance of lesions) occurred in one patient (14.28%), good improvement (51-75% clearance) in three patients (42.84%), moderate improvement (26-50% clearance) in two patients (28.57%), and mild improvement (1-25% clearance) in one patient (14.28%).
使用含有α-羟酸和β-羟酸的化学焕肤术已被用于改善色素沉着性痤疮瘢痕。乳酸是一种温和的α-羟酸,已被用于治疗各种皮肤科适应证,但尚无关于其治疗色素沉着性痤疮瘢痕的报道。
评估 92%(pH 值 2.0)高浓度纯乳酸化学焕肤术治疗印度人皮肤表浅性痤疮瘢痕的疗效和安全性。
7 例年龄 20-30 岁、Fitzpatrick 皮肤类型Ⅳ-Ⅴ的表浅性痤疮瘢痕患者纳入本研究。每 2 周进行 1 次乳酸化学焕肤术,最多进行 4 次。每次治疗前后均拍摄临床照片。末次治疗后 3 个月内每月随访 1 次以评估疗效。
治疗 3 个月后,治疗区域的质地、色素沉着和外观均有明显改善,瘢痕颜色变浅。1 例(14.28%)患者皮损完全清除(改善率>75%),3 例(42.84%)患者皮损显著改善(改善率 51%-75%),2 例(28.57%)患者皮损中度改善(改善率 26%-50%),1 例(14.28%)患者皮损轻度改善(改善率 1%-25%)。