白血病抗性（AKR×NZB）F1小鼠胸腺细胞对亲嗜性病毒的限制性表达。
Restricted expression of ecotropic virus by thymocytes of leukemia-resistant (AKR X NZB)F1 mice.
作者信息
Datta S K, Schwartz R S
出版信息
J Exp Med. 1978 Jul 1;148(1):329-34. doi: 10.1084/jem.148.1.329.
Abstract
AKR mice, which produce high titers of ecotropic virus, were crossed with NZB mice, which produce titers of xenotropic virus. Spleen, marrow, and lymph node cells of the F1 hybrid produced high titers of ecotropic and xenotropic viruses. However, expression of ecotropic virus by both thymus cells and peripheral T cells of the F1 was severely restricted. Despite simultaneous expression of ecotorpic and xenotropic viruses in F1 spleens, lymph nodes, and marrows evidence for recombinant viruses was not found. Such viruses were also undetectable in the F1 thymuses. The results indicate that a cellular mechanism, present in AKR thymus but lacking in the F1 influences virus expression and the formation of recombinant viruses. This may account for the low incidence of leukemia in the F1 hybrid.
摘要
能产生高滴度嗜亲性病毒的AKR小鼠与能产生异嗜性病毒滴度的NZB小鼠杂交。F1代杂种的脾脏、骨髓和淋巴结细胞产生了高滴度的嗜亲性和异嗜性病毒。然而，F1代的胸腺细胞和外周T细胞对嗜亲性病毒的表达受到严重限制。尽管在F1代的脾脏、淋巴结和骨髓中同时表达了嗜亲性和异嗜性病毒，但未发现重组病毒的证据。在F1代胸腺中也检测不到此类病毒。结果表明，存在于AKR胸腺但在F1代中缺乏的一种细胞机制影响病毒表达和重组病毒的形成。这可能是F1代杂种白血病发病率低的原因。
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