白细胞介素-1刺激β-淀粉样前体蛋白启动子。
Interleukin-1 stimulates the beta-amyloid precursor protein promoter.
作者信息
Donnelly R J, Friedhoff A J, Beer B, Blume A J, Vitek M P
机构信息
Millhauser Laboratories, Department of Psychiatry, NYU Medical Center, New York 10016.
出版信息
Cell Mol Neurobiol. 1990 Dec;10(4):485-95. doi: 10.1007/BF00712843.
Abstract
- Amyloid plaques found in the brains of Alzheimer's diseased patients are composed of the 42 amino acid beta-amyloid peptide (BAP) which is processed out of the larger amyloid precursor protein (APP). 2. To study the regulation of the APP gene expression, we have isolated the promoter region of this angle of this single-copy gene and produced a reporter gene system to determine if the promoter is responsive to agents that may cause the overproduction of APP leading to the abnormal accumulation of plaques in AD. 3. The promoter contains sequences homologous to heat shock elements, AP-1 binding sites, and phorbol ester-inducible sequences as well as GG-rich regions found in other constitutively expressed genes. 4. We show here that this promoter is inducible in cultured cells by interleukin-1 (IL-1) in a transient assay system and that the HSE and AP-1 binding site are required for this inducibility. 5. This induction of transcription from the APP promoter implies that this gene is responsive to tropic and/or trophic agents which may be present in the diseased brain.
摘要
- 在阿尔茨海默病患者大脑中发现的淀粉样斑块由42个氨基酸的β-淀粉样肽（BAP）组成，该肽是从较大的淀粉样前体蛋白（APP）加工而来的。2. 为了研究APP基因表达的调控，我们分离了这个单拷贝基因的启动子区域，并构建了一个报告基因系统，以确定该启动子是否对可能导致APP过度产生从而导致AD中斑块异常积累的因子有反应。3. 该启动子包含与热休克元件、AP-1结合位点、佛波酯诱导序列同源的序列，以及在其他组成性表达基因中发现的富含GG的区域。4. 我们在此表明，在瞬时检测系统中，该启动子在培养细胞中可被白细胞介素-1（IL-1）诱导，并且HSE和AP-1结合位点是这种诱导所必需的。5. APP启动子的这种转录诱导意味着该基因对患病大脑中可能存在的促生长和/或营养因子有反应。
相似文献
1
Interleukin-1 stimulates the beta-amyloid precursor protein promoter.白细胞介素-1刺激β-淀粉样前体蛋白启动子。
Cell Mol Neurobiol. 1990 Dec;10(4):485-95. doi: 10.1007/BF00712843.
2
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.白细胞介素1调节人内皮细胞中β淀粉样蛋白前体mRNA的合成。
Proc Natl Acad Sci U S A. 1989 Oct;86(19):7606-10. doi: 10.1073/pnas.86.19.7606.
3
The promoter of Alzheimer's disease amyloid A4 precursor gene.阿尔茨海默病淀粉样蛋白A4前体基因的启动子
EMBO J. 1988 Sep;7(9):2807-13. doi: 10.1002/j.1460-2075.1988.tb03136.x.
4
Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.编码β-淀粉样前体蛋白的基因的启动子活性受生长因子、佛波酯、视黄酸和白细胞介素-1的上调。
Brain Res Mol Brain Res. 1995 Sep;32(2):233-40. doi: 10.1016/0169-328x(95)00078-7.
5
6
The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences.编码阿尔茨海默病β-淀粉样前体蛋白（APP）的基因的启动子活性受两个上游序列区域调控。
Brain Res Mol Brain Res. 1991 Feb;9(3):253-7. doi: 10.1016/0169-328x(91)90009-m.
7
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.淀粉样斑块形成物种特有的APP基因中存在“CAGA框”，而在所有APLP - 1/2基因中均不存在：对阿尔茨海默病的影响。
FASEB J. 2004 Aug;18(11):1288-90. doi: 10.1096/fj.03-1703fje. Epub 2004 Jun 18.
8
Expression of human Alzheimer amyloid precursor protein in insect cells.人阿尔茨海默病淀粉样前体蛋白在昆虫细胞中的表达。
Biochem Biophys Res Commun. 1991 Jan 31;174(2):983-9. doi: 10.1016/0006-291x(91)91515-e.
9
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.在表达人淀粉样前体蛋白的海马神经元中产生含细胞内淀粉样片段，以及通过啮齿动物序列中的微小氨基酸取代防止淀粉样蛋白生成。
EMBO J. 1995 Oct 16;14(20):4932-8. doi: 10.1002/j.1460-2075.1995.tb00176.x.
10
Study of the Alzheimer's A4 precursor gene promoter region by genomic sequencing using Taq polymerase.
Biochem Biophys Res Commun. 1990 May 31;169(1):46-50. doi: 10.1016/0006-291x(90)91430-z.
引用本文的文献
1
The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease.非典型淀粉样β 异构体在阿尔茨海默病中的隐匿作用。
Cells. 2022 Oct 29;11(21):3421. doi: 10.3390/cells11213421.
2
Preclinical Marmoset Model for Targeting Chronic Inflammation as a Strategy to Prevent Alzheimer's Disease.针对慢性炎症作为预防阿尔茨海默病策略的临床前狨猴模型
Vaccines (Basel). 2021 Apr 15;9(4):388. doi: 10.3390/vaccines9040388.
3
Diclofenac reduces the risk of Alzheimer's disease: a pilot analysis of NSAIDs in two US veteran populations.双氯芬酸降低阿尔茨海默病风险：对美国两个退伍军人队列中使用非甾体抗炎药的初步分析
Ther Adv Neurol Disord. 2020 Jun 25;13:1756286420935676. doi: 10.1177/1756286420935676. eCollection 2020.
4
Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity.癫痫发作诱导的与海马突触可塑性相关的淀粉样β蛋白、STEP61及其底物的调节
Neural Plast. 2016;2016:2123748. doi: 10.1155/2016/2123748. Epub 2016 Apr 5.
5
Inflammation-sleep interface in brain disease: TNF, insulin, orexin.脑疾病中的炎症-睡眠界面：TNF、胰岛素、食欲素。
J Neuroinflammation. 2014 Mar 21;11:51. doi: 10.1186/1742-2094-11-51.
6
Amyloid-precursor-protein-lowering small molecules for disease modifying therapy of Alzheimer's disease.降低淀粉样前体蛋白的小分子药物用于阿尔茨海默病的疾病修饰治疗。
PLoS One. 2013 Dec 18;8(12):e82255. doi: 10.1371/journal.pone.0082255. eCollection 2013.
7
Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier.脂多糖损害脑内淀粉样β流出：血脑屏障血管隔离、脑脊液重吸收、外周清除和转运体功能改变。
J Neuroinflammation. 2012 Jun 29;9:150. doi: 10.1186/1742-2094-9-150.
8
Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons.α-突触核蛋白和β-淀粉样蛋白在成年大鼠神经元中的相互诱导。
Neurotox Res. 2013 Jan;23(1):69-78. doi: 10.1007/s12640-012-9330-y. Epub 2012 May 19.
9
Oxidative stress and β-amyloid protein in Alzheimer's disease.阿尔茨海默病中的氧化应激和 β-淀粉样蛋白。
Neuromolecular Med. 2011 Dec;13(4):223-50. doi: 10.1007/s12017-011-8155-9. Epub 2011 Sep 8.
10
Interleukin-1β with learning and memory.白细胞介素-1β与学习和记忆。
Neurosci Bull. 2010 Dec;26(6):455-68. doi: 10.1007/s12264-010-6023-5.
本文引用的文献
1
The role of protein kinase C in cell surface signal transduction and tumour promotion.蛋白激酶C在细胞表面信号转导及肿瘤促进中的作用。
Nature. 1984;308(5961):693-8. doi: 10.1038/308693a0.
2
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.一种编码阿尔茨海默病脑淀粉样蛋白的cDNA的特性及染色体定位
Science. 1987 Feb 20;235(4791):877-80. doi: 10.1126/science.3810169.
3
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease.大鼠外周和中枢组织以及人类中枢神经系统中的神经生长因子信使核糖核酸：大鼠脑内的损伤效应及阿尔茨海默病中的水平
Brain Res. 1986 Jul;387(1):85-92. doi: 10.1016/0169-328x(86)90023-9.
4
5
Multiple elements are required for expression of an intermediate filament gene.中间丝基因的表达需要多种元件。
Nucleic Acids Res. 1988 Aug 25;16(16):8057-76. doi: 10.1093/nar/16.16.8057.
6
Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.阿尔茨海默病患者大脑中β淀粉样蛋白信使核糖核酸的定位
Science. 1987 Jul 3;237(4810):77-80. doi: 10.1126/science.3299701.
7
Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.阿尔茨海默病中海马神经元亚群内β-淀粉样蛋白mRNA表达的差异调节。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1297-301. doi: 10.1073/pnas.85.4.1297.
8
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.基底核神经元的原位杂交显示，阿尔茨海默病中β-淀粉样蛋白信使核糖核酸增加。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1227-31. doi: 10.1073/pnas.85.4.1227.
9
Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.白细胞介素1可增强培养的大鼠成纤维细胞中编码神经生长因子的mRNA的稳定性并促进其转录。
J Biol Chem. 1988 Nov 5;263(31):16348-51.
10
Fos and Jun: the AP-1 connection.Fos与Jun：AP-1连接
Cell. 1988 Nov 4;55(3):395-7. doi: 10.1016/0092-8674(88)90024-4.
Zotero 插件