Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Respirology. 2010 Nov;15(8):1259-61. doi: 10.1111/j.1440-1843.2010.01845.x.
Acute fibrinous and organizing pneumonia (AFOP) is a disease of the small airways that is characterized by deposition of fibrin within the alveolar spaces. The histological pattern is described as a variant of cryptogenic organizing pneumonia (COP). Although COP has been occasionally described in patients with HIV infection, the variant form, AFOP, has not been previously reported in such patients. This report describes an intriguing case of AFOP in a patient with HIV infection and Pneumocystis jiroveci pneumonia. AFOP was diagnosed after tapering of corticosteroid therapy. This case illustrates that non-infectious pulmonary infiltrates should be considered in the differential diagnosis of lung disease in patients with HIV infection.
急性纤维蛋白性和机化性肺炎（AFOP）是一种小气道疾病，其特征是在肺泡腔内沉积纤维蛋白。组织学模式被描述为特发性机化性肺炎（COP）的一种变体。尽管COP 偶尔在 HIV 感染患者中描述过，但这种变体形式 AFOP 以前从未在这类患者中报道过。本报告描述了一例 HIV 感染和卡氏肺孢子菌肺炎患者中出现的有趣的 AFOP 病例。在皮质类固醇治疗减量后诊断出 AFOP。该病例说明，在 HIV 感染患者的肺部疾病鉴别诊断中，应考虑非感染性肺部浸润。
