人巨细胞病毒DNA。I. 分子量与感染性。
Human cytomegalovirus DNA. I. Molecular weight and infectivity.
作者信息
Geelen J L, Walig C, Wertheim P, van der Noordaa J
出版信息
J Virol. 1978 Jun;26(3):813-6. doi: 10.1128/JVI.26.3.813-816.1978.
Abstract
Human cytomegalovirus DNA (strain AD 169) was isolated from purified virions and further purified by sucrose density gradient centrifugation. The viral DNA molecules were studied by electron microscopy and found to be linear and to have a length of 76.22 +/- 5.22 micron, corresponding to a molecular weight of 147 +/- 6.2 x 10(6). The DNA was infectious when tested in human embryonic lung cells.
摘要
人巨细胞病毒DNA（AD169株）从纯化的病毒粒子中分离出来，并通过蔗糖密度梯度离心进一步纯化。通过电子显微镜研究病毒DNA分子，发现其为线性，长度为76.22±5.22微米，对应分子量为147±6.2×10⁶。在人胚肺细胞中进行测试时，该DNA具有感染性。
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