Department of Pharmaceutical Technology, Faculty of Pharmacy, Oporto University, Porto, Portugal.
Skin Res Technol. 2010 Nov;16(4):444-9. doi: 10.1111/j.1600-0846.2010.00458.x.
BACKGROUND/PURPOSE: Age has a huge influence on skin roughness; with increasing age, the number of collagen and elastine fibers is reduced and elasticity decreases significantly. Pharmaceutical and cosmetics, environmental factors and lifestyle have an important effect on skin. In this study, the efficacy of 12 commercial anti-wrinkle products was evaluated using a direct non-invasive method to measure the skin surface morphology. Four clinical parameters surface evaluation of the living skin (SELS) (Ser, Sesc, Sesm, and Sew) were evaluate using Visioscan(®) VC98.
Two hundred and forty-eight healthy female volunteers, aged between 30 and 70 years, were chosen for this study. The duration of treatment was 28 days. Skin microrelief parameters were evaluated using the Visioscan(®) VC98 - SELS 2000 from Courage+Khazaka. Measurements were made in the crow's feet area and the differences were evaluated for statistical significance.
Significant differences were found for some of the SELS parameters. According to the results obtained for SELS Sew, products that showed to be more effective against aging were V, M, N, T, P, R and L. We think this methodology may be considered very useful for the direct study of the skin surface and may be suitable as a routine method in wrinkle evaluation.
背景/目的：年龄对皮肤粗糙度有很大的影响；随着年龄的增长，胶原蛋白和弹性纤维的数量减少，弹性显著下降。药物和化妆品、环境因素和生活方式对皮肤有重要影响。在这项研究中，使用直接无创方法测量皮肤表面形态来评估 12 种商业抗皱产品的功效。使用 Visioscan(®) VC98 评估四个临床参数（SELS）（血清、SESC、Sesm 和 Sew）对活体皮肤的表面评估。
选择了 248 名年龄在 30 至 70 岁之间的健康女性志愿者进行这项研究。治疗时间为 28 天。使用 Courage+Khazaka 的 Visioscan(®) VC98-SELS 2000 评估皮肤微轮廓参数。在鱼尾纹区域进行测量，并评估差异的统计学意义。
一些 SELS 参数存在显著差异。根据 SELS Sew 的结果，显示对衰老更有效的产品有 V、M、N、T、P、R 和 L。我们认为这种方法可能被认为是研究皮肤表面非常有用的方法，并且可能适合作为皱纹评估的常规方法。
