Svennersten Karl, Larsson Karin C, Berggren Magnus, Richter-Dahlfors Agneta
Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Biochim Biophys Acta. 2011 Mar;1810(3):276-85. doi: 10.1016/j.bbagen.2010.10.001. Epub 2010 Oct 8.
Nanomedicine is a research area with potential to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. While the common goal with other fields of biomedicine is to solve medical problems, this area embraces an increasing number of technology platforms as they become miniaturized. Organic electronics has over the past two decades developed into an exciting and thriving area of research.
Today, the organic electronics field stands at the interface with biology. As the area of organic bioelectronics advances, it holds promise to make major contributions to nanomedicine. The progress made in this direction is the topic of this review.
We describe the inherent features of conducting polymers, and explain the usefulness of these materials as active scaffolds in cell biology and tissue engineering. We also explain how the combined ionic and electronic conductive nature of the polymers is used to precisely control the delivery of signal substances. This unique feature is key in novel devices for chemical communication with cells and tissues.
This review highlights the results from the creative melting pot of interdisciplinary research in organic bioelectronics. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine.
纳米医学是一个有望在未来几十年以革命性方式塑造、引导和改变未来医学治疗的研究领域。虽然生物医学其他领域的共同目标是解决医学问题，但随着技术平台的小型化，该领域涵盖了越来越多的技术平台。在过去二十年中，有机电子学已发展成为一个令人兴奋且蓬勃发展的研究领域。
如今，有机电子学领域处于与生物学的交叉点。随着有机生物电子学领域的发展，它有望为纳米医学做出重大贡献。这一方向上取得的进展是本综述的主题。
我们描述了导电聚合物的固有特性，并解释了这些材料作为细胞生物学和组织工程中活性支架的用途。我们还解释了聚合物的离子和电子传导特性如何结合起来精确控制信号物质的传递。这一独特特性是与细胞和组织进行化学通讯的新型设备的关键。
本综述突出了有机生物电子学跨学科研究这一创造性熔炉的成果。本文是名为《纳米技术——生物医学中的新兴应用》特刊的一部分。
