Department of Surgery, Kyungpook National University Hospital, Daegu, Korea.
Cancer Res Treat. 2010 Sep;42(3):130-4. doi: 10.4143/crt.2010.42.3.130. Epub 2010 Sep 30.
The aim of this study was to investigate the impact of a distal subtotal gastrectomy on the quality of life (QoL).
The QoL data of 126 patients were obtained on their 5th annual follow-up visit after a curative distal subtotal gastrectomy for gastric cancer (Group A). The QoL data of 130 age- and gender-adjusted healthy population were obtained from the individuals who visited the health screening center for a medical check-up (Group B). There were 42 women and 84 men in the study group and their mean age was 56.0±11.1 years. QoL was assessed using the Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire Core 30 (QLQ-C30) and QLQ-STO22.
The EORTC QLQ-C30 global health status and QoL scores of Group A and Group B were 63.9±22.7 and 61.3±22.1, respectively (p=0.361). Group A revealed a better score for emotional functioning (84.1±16.1 and 75.2±21.4, respectively; p<0.001), cognitive functioning (82.0±16.4 and 75.0±21.4, respectively; p=0.004) and fatigue (27.7±20.8 and 33.8±23.2, respectively; p=0.028). However, Group A revealed a worse score for nausea and vomiting (14.8±20.0 and 10.2±16.0, respectively; p=0.042), financial difficulties (14.8±22.9 and 7.1±16.1, respectively; p=0.002), reflux (16.7±17.7 and 10.1±17.0, respectively; p=0.003), eating restrictions (13.6±15.2 and 6.6±10.2, respectively; p<0.001) and body image (23.3±25.4 and 16.2±24.6, respectively; p=0.023).
The QoL of long-term survivors after a distal subtotal gastrectomy is still influenced by the surgery itself even though they are considered to be free of disease.
本研究旨在探讨远端胃大部切除术对生活质量(QoL)的影响。
对 126 例因胃癌行根治性远端胃大部切除术的患者在术后第 5 年进行随访(A 组),获得其 QoL 数据。从健康体检中心接受体检的 130 名年龄和性别匹配的健康人群中获得 QoL 数据(B 组)。研究组包括 42 名女性和 84 名男性,平均年龄为 56.0±11.1 岁。使用欧洲癌症研究与治疗组织(EORTC)生活质量问卷核心 30 项(QLQ-C30)和 QLQ-STO22 韩国版评估 QoL。
A 组和 B 组的 EORTC QLQ-C30 总体健康状况和 QoL 评分分别为 63.9±22.7 和 61.3±22.1(p=0.361)。A 组在情感功能(84.1±16.1 和 75.2±21.4,p<0.001)、认知功能(82.0±16.4 和 75.0±21.4,p=0.004)和疲劳(27.7±20.8 和 33.8±23.2,p=0.028)方面的评分更高,但在恶心和呕吐(14.8±20.0 和 10.2±16.0,p=0.042)、经济困难(14.8±22.9 和 7.1±16.1,p=0.002)、反流(16.7±17.7 和 10.1±17.0,p=0.003)、饮食限制(13.6±15.2 和 6.6±10.2,p<0.001)和身体形象(23.3±25.4 和 16.2±24.6,p=0.023)方面的评分更低。
即使认为远端胃大部切除术患者无疾病,但手术本身仍会影响长期生存者的生活质量。