Dillner Joakim, Andersson Kristin
Bio Banking and Molecular Resource, Infrastructure of Sweden (BBMRIse), Karolinska Institutet, Stockholm, Sweden.
Methods Mol Biol. 2011;675:113-25. doi: 10.1007/978-1-59745-423-0_4.
The routine health services collect large amount of samples for biobanking, particularly in clinical laboratory medicine, mainly for clinical diagnostic purposes. These samples provide a large-scale and clinically relevant biobanking infrastructure that can be used for research if these conditions apply. There must be a system for database management that can obtain data on clinical endpoints, vital status, and additional required information via registry linkages. There must be an appropriate ethical system for handling consent for research use. There should be an active effort to optimize the usefulness of clinical biobanks also for research use. Major steps in this direction include measures to stop the ongoing discarding of old samples, reformatting to minimize pick-up times, external quality assurance and formal accreditation of biobanks, building of a dedicated high-quality database that is regularly used for registry linkages, and considerations on whether usefulness and accessibility for research can be optimized by extended saving or pre-treatment of samples. Systematic clinical biobanking could become a major asset for clinical research and public health if biobanking is considered as a routine part of everyday clinical practice, and the science of biobanking is considered an essential part of the science of laboratory medicine.
常规卫生服务机构收集大量样本用于生物样本库建设，尤其是在临床检验医学领域，主要用于临床诊断目的。如果符合相关条件，这些样本可提供一个大规模且与临床相关的生物样本库基础设施，用于研究。必须有一个数据库管理系统，该系统能够通过登记链接获取临床终点、生命状态及其他所需信息的数据。必须有一个适当的伦理体系来处理研究使用的同意事宜。还应积极努力优化临床生物样本库对研究使用的效用。朝这个方向采取的主要步骤包括采取措施停止持续丢弃旧样本、重新规划以尽量减少提取时间、对生物样本库进行外部质量保证和正式认证、建立一个定期用于登记链接的专用高质量数据库，以及考虑是否可以通过延长样本保存时间或进行预处理来优化样本对研究的效用和可及性。如果将生物样本库视为日常临床实践的常规组成部分，且生物样本库科学被视为检验医学科学的重要组成部分，那么系统的临床生物样本库建设可能会成为临床研究和公共卫生的一项重要资产。
