Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
Reprod Toxicol. 2011 Feb;31(2):171-6. doi: 10.1016/j.reprotox.2010.10.005. Epub 2010 Oct 15.
Observations in several western and Asiatic countries point toward a decline in semen quality which may be associated with environmental exposures. To investigate the effect of environmental exposure to pyrethroids on sperm DNA integrity and semen quality, 240 men were recruited from an infertility clinic through the clinic following strict eligibility screening. Urinary 3-phenoxybenzoic acid (3-PBA) concentration, semen quality, and sperm DNA integrity were evaluated. After adjustment for potential confounders, a significant inverse correlation was observed between the urinary 3-PBA level and the sperm concentration (β=-0.27, 95%CI: -0.41 to -0.12, P<0.001). Moreover, we also found a significant positive correlation between urinary 3-PBA level and sperm DNA fragmentation (β=0.27, 95%CI: 0.15-0.39, P<0.001). Our results suggest that non-occupational environmental pyrethroids exposure may have a negative impact on sperm DNA integrity and semen quality in Chinese males.
一些西方国家和亚洲国家的观察结果表明，精液质量可能下降，这可能与环境暴露有关。为了研究环境中拟除虫菊酯暴露对精子 DNA 完整性和精液质量的影响，我们从一家不孕不育诊所通过严格的资格筛选招募了 240 名男性。评估了尿液中 3-苯氧基苯甲酸（3-PBA）浓度、精液质量和精子 DNA 完整性。在调整了潜在的混杂因素后，发现尿液中 3-PBA 水平与精子浓度呈显著负相关（β=-0.27，95%CI：-0.41 至-0.12，P<0.001）。此外，我们还发现尿液中 3-PBA 水平与精子 DNA 碎片化呈显著正相关（β=0.27，95%CI：0.15-0.39，P<0.001）。我们的研究结果表明，非职业性环境拟除虫菊酯暴露可能对中国男性的精子 DNA 完整性和精液质量产生负面影响。
