Philips Research Europe, High Tech Campus 4, 5656 AE Eindhoven, The Netherlands.
Phys Med Biol. 2010 Nov 7;55(21):6461-73. doi: 10.1088/0031-9155/55/21/008. Epub 2010 Oct 19.
The potential of red blood cells (RBCs) loaded with iron oxide nanoparticles as a tracer material for magnetic particle imaging (MPI) has been investigated. MPI is an emerging, quantitative medical imaging modality which holds promise in terms of sensitivity in combination with spatial and temporal resolution. Steady-state and dynamic magnetization measurements, supported by semi-empirical modeling, were employed to analyze the MPI signal generation using RBCs as novel biomimetic constructs. Since the superparamagnetic iron oxide (SPIO) bulk material that is used in this study contains nanoparticles with different sizes, it is suggested that during the RBC loading procedure, a preferential entrapment of nanoparticles with hydrodynamic diameter ≤60 nm occurs by size-selection through the erythrocyte membrane pores. This affects the MPI signal of an erythrocyte-based tracer, compared to bulk. The reduced signal is counterbalanced by a higher in vivo stability of the SPIO-loaded RBCs constructs for MPI applications.
已经研究了负载氧化铁纳米颗粒的红细胞 (RBC) 作为磁性粒子成像 (MPI) 示踪材料的潜力。MPI 是一种新兴的定量医学成像方式，在灵敏度方面具有结合空间和时间分辨率的优势。稳态和动态磁化测量，辅以半经验模型，用于分析使用 RBC 作为新型仿生构建体产生的 MPI 信号。由于本研究中使用的超顺磁氧化铁 (SPIO) 块状材料包含不同尺寸的纳米颗粒，因此建议在 RBC 装载过程中，通过红细胞膜孔的尺寸选择优先捕获直径≤60nm 的纳米颗粒。这会影响基于红细胞示踪剂的 MPI 信号，与块状物相比。这种减少的信号通过负载 SPIO 的 RBC 构建体在体内更高的稳定性来平衡，适用于 MPI 应用。
