Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Am J Ophthalmol. 2010 Dec;150(6):815-24. doi: 10.1016/j.ajo.2010.06.025. Epub 2010 Oct 20.
To compare retinal thickness measurements produced by different time-domain and spectral-domain optical coherence tomography (TD-OCT and SD-OCT) devices when imaging normal and pathologic eyes.
Prospective, observational study in an academic institutional setting.
A total of 110 eyes were imaged by 6 different OCT devices: Stratus and Cirrus (Carl Zeiss Meditec Inc), Spectralis HRA+OCT (Heidelberg Engineering), RTVue-100 (Optovue Inc), SDOCT Copernicus HR (Optopol Technology S.A.), and 3D OCT-1000 (Topcon Corporation). Eyes were normal or affected by different pathologies of the retina, including exudative and nonexudative age-related macular degeneration, epiretinal membrane, cystoid macular edema, and macular hole. For each instrument we used standard analysis protocols for macular thickness evaluation. Mean retinal thickness values between the instruments in the ETDRS central circular 1000-μm-diameter areas and in the ETDRS midperipheral circular 3000-μm-diameter areas were compared.
The 6 different devices produced measurements that differ in variance (Bartlett test, P = .006), and mean values (Friedman test, P < .001). Bland-Altman analysis revealed that the limits of agreement for all the comparisons were not acceptable. Regression was calculated and it was elaborated into a conversion table, despite a high standard error for both intercepts and slope conversion values.
This study suggests that retinal thickness measurements obtained with various OCT devices are different beyond clinical practice tolerance, according to Bland-Altman analysis. Furthermore, regression analysis reveals high standard error values. These differences appear to be primarily attributable to the analysis algorithms used to set retinal inner and outer boundaries.
比较不同时域和频域光相干断层扫描（TD-OCT 和 SD-OCT）设备在正常和病理眼成像时的视网膜厚度测量值。
在学术机构环境中进行的前瞻性观察研究。
使用 6 种不同的 OCT 设备对 110 只眼睛进行成像：Stratus 和 Cirrus（卡尔蔡司医学技术公司）、Spectralis HRA+OCT（海德堡工程公司）、RTVue-100（Optovue 公司）、SDOCT Copernicus HR（Optopol 技术公司）和 3D OCT-1000（Topcon 公司）。眼睛正常或受视网膜不同病变影响，包括渗出性和非渗出性年龄相关性黄斑变性、视网膜前膜、囊样黄斑水肿和黄斑裂孔。对于每种仪器，我们都使用了黄斑厚度评估的标准分析方案。比较了仪器在 ETDRS 中央圆形 1000μm 直径区域和 ETDRS 中周边圆形 3000μm 直径区域的平均视网膜厚度值。
6 种不同的设备产生的测量值在方差（Bartlett 检验，P=.006）和平均值（Friedman 检验，P<.001）方面存在差异。Bland-Altman 分析显示，所有比较的一致性界限都不可接受。尽管截距和斜率转换值的标准误差都很高，但仍进行了回归分析，并编制了转换表。
根据 Bland-Altman 分析，本研究表明，各种 OCT 设备获得的视网膜厚度测量值存在差异，超出了临床实践的可接受范围。此外，回归分析显示标准误差值较高。这些差异似乎主要归因于用于设置视网膜内界和外界边界的分析算法。
