Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive-0130, La Jolla, California 92093-0130, USA.
Nat Rev Mol Cell Biol. 2010 Nov;11(11):764-76. doi: 10.1038/nrm2995.
An intrinsic clock enables an organism to anticipate environmental changes and use energy sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock to orchestrate rhythms is also important for human health. The use of systems biology approaches has advanced our understanding of mechanistic features of circadian oscillators over the past decade. The field is now in a position to develop a multiscale view of circadian systems, from the molecular level to the intact organism, and to apply this information for the development of new therapeutic strategies or for enhancing agricultural productivity in crops.
内在时钟使生物体能够预测环境变化并更有效地利用能源，从而赋予其适应优势。对于人类健康而言，拥有一个内在时钟来协调节律也很重要。在过去的十年中，系统生物学方法的应用推动了我们对生物钟振荡器机制特征的理解。该领域现在已经能够从分子水平到完整的生物体，对生物钟系统进行多尺度的观察，并将这些信息应用于开发新的治疗策略或提高作物的农业生产力。
