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Central carbon metabolism of Plasmodium parasites.疟原虫的中心碳代谢
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Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis.实现原生动物寄生虫无偏代谢组学分析:优化适合亲水作用色谱-轨道阱分析的利什曼原虫采样方案。
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Branched tricarboxylic acid metabolism in Plasmodium falciparum.疟原虫中的支链三羧酸代谢。
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Genomic and metabolomic advances in the identification of disease and adverse event biomarkers.基因组学和代谢组学在疾病和不良事件生物标志物鉴定方面的进展。
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Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression.尿液、血清和脑组织代谢组学谱的改变在疟疾疾病进展过程中表现出性别二态性。
Malar J. 2010 Apr 23;9:110. doi: 10.1186/1475-2875-9-110.
6
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels.恶性疟原虫精脒合酶抑制导致转录本、蛋白质和代谢物水平出现独特的、受扰动影响的变化。
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Multivariate paired data analysis: multilevel PLSDA versus OPLSDA.多变量配对数据分析:多层偏最小二乘判别分析与正交偏最小二乘判别分析
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Eating at the table of another: metabolomics of host-parasite interactions.共餐:宿主-寄生虫相互作用的代谢组学。
Cell Host Microbe. 2010 Feb 18;7(2):90-9. doi: 10.1016/j.chom.2010.01.008.
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Fast sampling for quantitative microbial metabolomics.快速采样用于定量微生物代谢组学。
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The evolution, metabolism and functions of the apicoplast.类质体的进化、代谢和功能。
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代谢组学与疟疾生物学

Metabolomics and malaria biology.

作者信息

Lakshmanan Viswanathan, Rhee Kyu Y, Daily Johanna P

机构信息

Department of Medicine, Infectious Diseases Division, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.

出版信息

Mol Biochem Parasitol. 2011 Feb;175(2):104-11. doi: 10.1016/j.molbiopara.2010.09.008. Epub 2010 Oct 21.

DOI:10.1016/j.molbiopara.2010.09.008
PMID:20970461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3004989/
Abstract

Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It has provided researchers with a platform to combine powerful biochemical, statistical, computational, and bioinformatics techniques to delve into the mysteries of biology and disease. The application of metabolomics to study malaria parasites represents a major advance in our approach towards gaining a more comprehensive perspective on parasite biology and disease etiology. This review attempts to highlight some of the important aspects of the field of metabolomics, and its ongoing and potential future applications to malaria research.

摘要

代谢组学在生物学研究中开创了一个全新的多学科领域。它为研究人员提供了一个平台,可结合强大的生化、统计、计算和生物信息学技术,深入探究生物学和疾病的奥秘。代谢组学在研究疟原虫方面的应用代表了我们在更全面了解寄生虫生物学和疾病病因学的方法上取得的重大进展。本综述旨在突出代谢组学领域的一些重要方面,以及其在疟疾研究中的现有和潜在未来应用。