State Key Lab of Agrobiotechnology, China Agricultural University, Beijing, China.
Nat Genet. 2010 Nov;42(11):1027-30. doi: 10.1038/ng.684. Epub 2010 Oct 24.
We have resequenced a group of six elite maize inbred lines, including the parents of the most productive commercial hybrid in China. This effort uncovered more than 1,000,000 SNPs, 30,000 indel polymorphisms and 101 low-sequence-diversity chromosomal intervals in the maize genome. We also identified several hundred complete genes that show presence/absence variation among these resequenced lines. We discuss the potential roles of complementation of presence/absence variations and other deleterious mutations in contributing to heterosis. High-density SNP and indel polymorphism markers reported here are expected to be a valuable resource for future genetic studies and the molecular breeding of this important crop.
我们对包括中国最主要的商业化杂交种亲本在内的 6 个优秀玉米自交系进行了重测序。该研究共发现了超过 100 万个 SNPs、30000 个插入缺失多态性和 101 个低序列多样性的玉米基因组染色体区间。我们还鉴定了几百个在这些重测序系中存在/缺失变异的完整基因。我们讨论了存在/缺失变异的互补作用和其他有害突变在杂种优势形成中的潜在作用。本文报道的高密度 SNP 和插入缺失多态性标记有望成为未来该重要作物遗传研究和分子育种的宝贵资源。
