Lambrecht L K, Barsotti D A, Allen J R
Environ Health Perspect. 1978 Apr;23:139-45. doi: 10.1289/ehp.7823139.
In a series of experiments, rhesus monkeys have been given in their diets 0.3, 1.5, and 25 ppm of a commercial polybrominated biphenyl (PBB) (as FireMaster FF-1). The seven adult female monkeys receiving 0.3 ppm PBB have been on the treatment regime for 15 months and have consumed over 22 mg of PBB. During the initial 6 months of exposure, they lost weight and 2 of the animals develop sterile abscesses. At 6 months, 4 of the 7 animals had flattened and lengthened serum progesterone peaks. This change was correlated with an increase in length of their menstrual cycles. After 6 months of PBB exposure, the animals were bred. Two of the 7 animals showed excessive and prolonged implantation bleeding. Two abortions and 5 live births were recorded. All of the experimental infants were smaller than the controls at birth. The animals receiving a diet containing 1.5 ppm PBB for 36 weeks (total intake 70 mg) have shown a moderate weight loss and decrease in serum cholesterol. Similar changes have also been recorded in the group given the 25 ppm PBB diet for 14 weeks (approximately 500 mg total intake). In addition, these animals have also developed a hyperplastic gastritis.
在一系列实验中，给恒河猴的饮食中添加了0.3、1.5和25 ppm的一种商业多溴联苯（PBB）（商品名为FireMaster FF - 1）。接受0.3 ppm PBB的7只成年雌性猴子已接受该治疗方案15个月，摄入的PBB超过22毫克。在最初接触的6个月里，它们体重减轻，其中2只动物出现无菌性脓肿。6个月时，7只动物中有4只血清孕酮峰值变平且延长。这种变化与它们月经周期长度的增加相关。PBB暴露6个月后，这些动物进行了繁殖。7只动物中有2只出现过度且持续时间长的着床出血。记录到2次流产和5次活产。所有实验婴儿出生时都比对照组小。接受含1.5 ppm PBB饮食36周（总摄入量70毫克）的动物出现了中度体重减轻和血清胆固醇降低。在给予25 ppm PBB饮食14周（总摄入量约500毫克）的组中也记录到了类似变化。此外，这些动物还患上了增生性胃炎。
