大环四唑的合成用于快速光诱导生物正交 1,3-偶极环加成反应。
Synthesis of macrocyclic tetrazoles for rapid photoinduced bioorthogonal 1,3-dipolar cycloaddition reactions.
机构信息
Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA.
出版信息
Chemistry. 2010 Dec 3;16(45):13325-9. doi: 10.1002/chem.201002360.
Abstract
A series of conformationally constrained, macrocyclic tetrazoles were expediently prepared by double alkylation of a bis(-phenolyl)tetrazole precursor. Several of them showed excellent reactivity toward norbornene in a photoinduced tetrazole-alkene cycloaddition reaction in organic solvent as well as toward a norbornene-modified protein in PBS buffer.
摘要
一系列构象受限的大环四唑可通过双-（-苯氧基）四唑前体的双烷基化反应方便地制备。其中一些在有机溶剂中的光诱导四唑-烯烃环加成反应以及在 PBS 缓冲液中的降冰片烯修饰蛋白中表现出优异的反应活性。
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