Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Chemistry. 2010 Dec 3;16(45):13325-9. doi: 10.1002/chem.201002360.
A series of conformationally constrained, macrocyclic tetrazoles were expediently prepared by double alkylation of a bis(-phenolyl)tetrazole precursor. Several of them showed excellent reactivity toward norbornene in a photoinduced tetrazole-alkene cycloaddition reaction in organic solvent as well as toward a norbornene-modified protein in PBS buffer.
一系列构象受限的大环四唑可通过双-（-苯氧基）四唑前体的双烷基化反应方便地制备。其中一些在有机溶剂中的光诱导四唑-烯烃环加成反应以及在 PBS 缓冲液中的降冰片烯修饰蛋白中表现出优异的反应活性。
