Passaleva A, Massai G, Matucci-Cerinic M, Domeneghetti M P, Sharifian J, Lotti T, Cagnoni M, Ricci M
Cattedra di Allergologia e Immunologia Clinica, University of Florence, Italy.
Autoimmunity. 1990;6(4):283-91. doi: 10.3109/08916939008998420.
Antinuclear antibodies, circulating immune complexes, rheumatoid factors and anticardiolipin antibodies were detected in the sera of 17 patients affected by the limited cutaneous subset of systemic sclerosis and marked clinical evidence of ischaemic cutaneous lesions (fingertip ulcerations). This study was designed to evaluate the possible role of anticardiolipin (aCL) antibodies and other immunological disorders in the endothelial damage characteristic of the disease. ACL antibodies were found in 41% of the patients. With the exception of a significant connection with positive rheumatoid factor tests (RIA), no notable associations between anticardiolipin antibodies and antinuclear antibodies, circulating immune complexes (CIC), and other serological abnormalities were found. ACL antibodies did not significantly correlate with the presence of vascular lesions in our patients. However, a role of these antibodies in endothelial damage cannot be excluded, possibly in association with other serum factors such as immune complexes and antinuclear antibodies. A positive connection between the incidence of CIC and the severity of lung perfusion impairment was observed, and the previously reported relationship between anticentromere antibodies and calcinosis was indirectly confirmed.
在17例患有系统性硬化症局限性皮肤亚型且有明显缺血性皮肤病变（指尖溃疡）临床证据的患者血清中，检测了抗核抗体、循环免疫复合物、类风湿因子和抗心磷脂抗体。本研究旨在评估抗心磷脂（aCL）抗体及其他免疫紊乱在该疾病特征性内皮损伤中的可能作用。41%的患者检测到ACL抗体。除与类风湿因子检测（RIA）呈阳性有显著关联外，未发现抗心磷脂抗体与抗核抗体、循环免疫复合物（CIC）及其他血清学异常之间有明显关联。ACL抗体与我们患者血管病变的存在无显著相关性。然而，不能排除这些抗体在内皮损伤中的作用，可能与免疫复合物和抗核抗体等其他血清因子有关。观察到CIC发生率与肺灌注损害严重程度呈正相关，间接证实了先前报道的抗着丝点抗体与钙质沉着之间的关系。
