Sabol F, Vasilenko T, Novotný M, Tomori Z, Bobrov N, Zivčák J, Hudák R, Gál P
Clinic of Heart Surgery, East-Slovak Institute for Cardiovascular Diseases, Košice, Slovak Republic.
Eur Surg Res. 2010;45(3-4):321-6. doi: 10.1159/000320837. Epub 2010 Oct 29.
Although tissue adhesives and traditional sutures were compared in numerous studies during the early stages of healing, it has to be clarified, from the histological and biomechanical point of view, how the differences develop during the later phases.
Twenty-four male Sprague-Dawley rats were used and divided into 2 groups: the IRS (intradermal running suture) and G (glue) groups. Two parallel full-thickness skin incisions were made on the back of each rat. Wounds in the IRS group were closed by an IRS, whereas wounds in the G group were closed using tissue adhesive (n-butylcyanoacrylate). Rats were sacrificed 7 and 22 days after surgery.
Similar wound tensile strengths of glued and sutured wounds were measured on days 7 (IRS = 10.3 ± 1.7 g/mm(2) vs. G = 12.9 ± 4.0 g/mm(2), p = 0.9612) and 22 (IRS = 95.6 ± 15.7 g/mm(2) vs. G = 85.6 ± 16.4 g/mm(2), p = 0.2502) after surgery. Histology revealed a significantly increased amount of granulation tissue formation in glued wounds on day 7. The difference in granulation tissue formation was reduced until day 22.
Tissue adhesive based on n-butylcyanoacrylate presents a fair alternative to traditional suture wound closure techniques.
尽管在愈合早期的众多研究中对组织粘合剂和传统缝线进行了比较，但从组织学和生物力学角度来看，后期差异如何发展仍有待阐明。
使用24只雄性Sprague-Dawley大鼠，分为2组：皮内连续缝合（IRS）组和胶水（G）组。在每只大鼠背部制作两条平行的全层皮肤切口。IRS组的伤口用IRS缝合，而G组的伤口用组织粘合剂（正丁基氰基丙烯酸酯）封闭。术后7天和22天处死大鼠。
术后7天（IRS = 10.3±1.7 g/mm² vs. G = 12.9±4.0 g/mm²，p = 0.9612）和22天（IRS = 95.6±15.7 g/mm² vs. G = 85.6±16.4 g/mm²，p = 0.2502）时，测量的胶水封闭伤口和缝合伤口的伤口抗张强度相似。组织学显示，胶水封闭伤口在第7天肉芽组织形成量显著增加。直到第22天，肉芽组织形成的差异才减小。
基于正丁基氰基丙烯酸酯的组织粘合剂是传统缝线伤口闭合技术的一个合理替代方案。
